Date of this Version
The Annals of Statistics
It is shown that the standard two one-sided tests procedure for bioequivalence is a biased test. Better tests exist. In this paper, an unbiased α-level test and other tests which are uniformly more powerful than the two one-sided tests procedure are constructed. Its power can be noticeably larger than that of the α-level two one-sided tests procedure.
two one-sided tests procedure, uniformly more powerful, pharmocokinetic parameters
Brown, L. D., Hwang, J., & Munk, A. (1997). An Unbiased Test for the Bioequivalence Problem. The Annals of Statistics, 25 (6), 2345-2367. http://dx.doi.org/10.1214/aos/1030741076
Date Posted: 27 November 2017
This document has been peer reviewed.