Date of this Version
Current Opinion in Colloid & Interface Science
Tethered particle motion is an experimental technique to monitor conformational changes in single molecules of DNA in real time, by observing the position fluctuations of a micrometer-size particle attached to the DNA. This article reviews some recent work on theoretical problems inherent in the interpretation of TPM experiments, both in equilibrium and dynamical aspects.
Tethered motion, Hidden Markov, DNA conformation, DNA looping, Single-particle tracking
Nelson, P. C. (2007). Colloidal Particle Motion as a Diagnostic of DNA Conformational Transitions. Current Opinion in Colloid & Interface Science, 12 (6), 307-313. http://dx.doi.org/10.1016/j.cocis.2007.07.015
Date Posted: 01 May 2017
This document has been peer reviewed.