Department of Physics Papers

Document Type

Journal Article

Date of this Version

11-2007

Publication Source

Europhysics Letters

Volume

81

Issue

1

DOI

10.1209/0295-5075/81/18001

Abstract

We propose an alternative mechanism for intracellular cargo transport which results from motor-induced longitudinal fluctuations of cytoskeletal microtubules (MTs). The longitudinal fluctuations combined with transient cargo binding to the MTs lead to long-range transport even for cargos and vesicles having no molecular motors on them. The proposed transport mechanism, which we call “hitchhiking”, provides a possible explanation for the broadly observed yet still mysterious phenomenon of bidirectional transport along MTs. We show that cells exploiting the hitchhiking mechanism can effectively up- and down-regulate the transport of different vesicles by tuning their binding kinetics to characteristic MT oscillation frequencies.

Included in

Physics Commons

Share

COinS
 

Date Posted: 15 March 2017

This document has been peer reviewed.