Department of Physics Papers
Document Type
Journal Article
Date of this Version
4-17-2012
Abstract
Diffuse correlation spectroscopy (DCS) is a novel optical technique that appears to be an excellent tool for assessing cerebral blood flow in a continuous and non-invasive manner at the bedside. We present new clinical validation of the DCS methodology by demonstrating strong agreement between DCS indices of relative cerebral blood flow and indices based on phase-encoded velocity mapping magnetic resonance imaging (VENC MRI) of relative blood flow in the jugular veins and superior vena cava. Data were acquired from 46 children with single ventricle cardiac lesions during a hypercapnia intervention. Significant increases in cerebral blood flow, measured both by DCS and by VENC MRI, as well as significant increases in oxyhemoglobin concentration, and total hemoglobin concentration, were observed during hypercapnia. Comparison of blood flow changes measured by VENC MRI in the jugular veins and by DCS revealed a strong linear relationship, R = 0.88, p < 0.001, slope = 0.91 ± 0.07. Similar correlations were observed between DCS and VENC MRI in the superior vena cava, R = 0.77, slope = 0.99 ± 0.12, p < 0.001. The relationship between VENC MRI in the aorta and DCS, a negative control, was weakly correlated, R = 0.46, slope = 1.77 ± 0.45, p < 0.001.
Recommended Citation
Buckley, E. M., Hance, D., Pawlowski, T., Lynch, J., Wilson, F. B., Mesquita, R. C., Durduran, T., Diaz, L. K., Putt, M. E., Licht, D. J., Fogel, M. A., & Yodh, A. G. (2012). Validation of Diffuse Correlation Spectroscopic Measurement of Cerebral Blood Flow Using Phase-Encoded Velocity Mapping Magnetic Resonance Imaging. Retrieved from https://repository.upenn.edu/physics_papers/273
Date Posted: 27 February 2013
This document has been peer reviewed.
Comments
Buckley E. M., Hance D., Pawlowski T., et al. (2012) Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging. Journal of Biomedical Optics, 17(3):037007-1-037007-8. doi: 10.1117/1.JBO.17.3.037007
Copyright 2012 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.