Department of Physics Papers

Document Type

Journal Article

Date of this Version



We implemented a nanoelectronic interface between graphene field effect transistors (FETs) and soluble proteins. This enables production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. The method serves to link polyhistidine-tagged proteins to graphene FETs using the tag itself. Atomic force microscopy and Raman spectroscopy provide structural understanding of the bio/nano hybrid; current-gate voltage measurements are used to elucidate the electronic properties. As an example application, we functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein.


Suggested Citation:
Lu, Y., Lerner, M. B., Qi, Z. J., Mitala, J., Lim, J. H., Discher, B. M., & Johnson, A. T. C. (2012). Graphene-protein bioelectronic devices with wavelength-dependent photoresponse. Applied Physics Letters, 100, 033110.

© 2012 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters and may be found at


atomic force microscopy, biomolecular electronics, field effect transistors, fluorescence, graphene, molecular biophysics, nanobiotechnology, proteins, Raman spectra, visible spectra



Date Posted: 20 January 2012

This document has been peer reviewed.