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We implemented a nanoelectronic interface between graphene field effect transistors (FETs) and soluble proteins. This enables production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. The method serves to link polyhistidine-tagged proteins to graphene FETs using the tag itself. Atomic force microscopy and Raman spectroscopy provide structural understanding of the bio/nano hybrid; current-gate voltage measurements are used to elucidate the electronic properties. As an example application, we functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein.
atomic force microscopy, biomolecular electronics, field effect transistors, fluorescence, graphene, molecular biophysics, nanobiotechnology, proteins, Raman spectra, visible spectra
Lu, Y., Lerner, M. B., Qi, Z. J., Mitala, J. J., Lim, J. H., Discher, B. M., & Johnson, A. (2012). Graphene-Protein Bioelectronic Devices with Wavelength-Dependent Photoresponse. Retrieved from https://repository.upenn.edu/physics_papers/218
Date Posted: 20 January 2012
This document has been peer reviewed.