Date of this Version
Branched actin networks at the leading edge of a crawling cell evolve via protein-regulated processes such as polymerization, depolymerization, capping, branching, and severing. A formulation of these processes is presented and analyzed to study steady-state network morphology. In bulk, we identify several scaling regimes in severing and branching protein concentrations and find that the coupling between severing and branching is optimally exploited for conditions in vivo. Near the leading edge, we find qualitative agreement with the in vivo morphology.
Gopinathan, A., Lee, K., Schwarz, J., & Liu, A. J. (2007). Branching, Capping, and Severing in Dynamic Actin Structures. Retrieved from https://repository.upenn.edu/physics_papers/146
Date Posted: 12 May 2011
This document has been peer reviewed.