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We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHbT/N=69±21%), oxyhemoglobin (rctO2HbT/N=73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N=75±7% on day 7 with respect to day 0). Our observation suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.
breast cancer, diffuse correlation spectroscopy, blood flow, diffuse optical spectroscopy, neoadjuvant chemotherapy, early monitoring, oxygen metabolism
Zhou, C., Choe, R., Shah, N., Durduran, T., Yu, G., Durkin, A., Hsiang, D., Mehta, R., Butler, J., Cerussi, A., Tromberg, B. J., & Yodh, A. G. (2007). Diffuse Optical Monitoring of Blood Flow and Oxygenation in Human Breast Cancer During Early Stages of Neoadjuvant Chemotherapy. Retrieved from https://repository.upenn.edu/physics_papers/143
Date Posted: 12 May 2011
This document has been peer reviewed.