Departmental Papers (Department of Systems Pharmacology and Translational Therapeutics)

Departmental Papers (Department of Systems Pharmacology and Translational Therapeutics)

 
Systems Pharmacology and Translational Therapeutics involves the discovery of new drugs, the investigation of how drugs work and the use of drugs to probe mechanisms of disease. But pharmacology also involves the elucidation and manipulation of macromolecular structures, the analysis of regulatory mechanisms in cell biology and development, and the translation of this information into clinical research. Thus, the science of pharmacology spans the most fundamental aspects of basic research, through transgenic animal models, to clinical investigation. Pharmacology at Penn addresses all of these issues in an exciting, collegial and interactive environment.

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Submissions from 2017

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Histone Posttranslational Modifications Predict Specific Alternative Exon Subtypes in Mammalian Brain, Qiwen Hu, Eun J. Kim, Jian Feng, Gregory R. Grant, and Elizabeth A. Heller

Submissions from 2016

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Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocain- and Stress-Evoked Behavior, Elizabeth A. Heller, Peter J. Hamilton, Dominika D. Burek, Sonia I. Lombroso, Catherine J. Peña, Rachael L. Neve, and Eric J. Nestler

Submissions from 2015

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SIRT1-FOXO3a Regulate Cocain Actions in the Nucleus Accumbens, Deveroux Ferguson, Ningyi Shao, Elizabeth A. Heller, Jian Feng, Rachael L. Neve, Hee-Dae Kim, Li Shen, and Eric J. Nestler

Submissions from 2013

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Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocain and Morphine Action, Deveroux Ferguson, Ja Wook Koo, Jian Feng, Elizabeth A. Heller, Jacqui Rabkin, Mitra Heshmati, William Renthal, Xiaochuan Liu, Ningyi Shao, Vittorio Sartorelli, Li Shen, and Eric J. Nestler

Submissions from 2012

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The Biochemical Anatomy of Cortical Inhibitory Synapses, Elizabeth A. Heller, Wenzhu Zhang, Fekrije Selimi, John C. Earnheart, Marta A. Ślimak, Julio Santos-Torres, Ines Ibañez-Tallon, Chiye Aoki, Brian T. Chait, and Nathaniel Heintz

Submissions from 2009

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Proteomic Studies of a Single CNS Synapse Type: The Parallel Fiber/Purkinje Cell Synapse, Fekrije Selimi, Ileana M. Cristea, Elizabeth A. Heller, Brian T. Chait, and Nathaniel Heintz

Submissions from 2003

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Sleep Deprivation Selectively Impairs Memory Consolidation for Contextual Fear Conditioning, Laurel A. Graves, Elizabeth A. Heller, Allan I. Pack, and Ted Abel