Document Type

Journal Article

Date of this Version

3-14-2018

Embargo Date

4-2019

Publication Source

Biological Research for Nursing

Volume

20

Issue

4

Start Page

410

Last Page

421

DOI

10.1177/1099800418764326

Abstract

Fatigue, a commonly reported symptom, is defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. To date, cancer researchers have been in the forefront in investigating the possible biological mechanisms of fatigue, identifying inflammation, dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, and activation of the autonomic nervous system. The purpose of this systematic review is to describe fatigue and what is known about the biological mechanisms described in cancer in five chronic, noninfectious illnesses: heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, and chronic obstructive pulmonary disease. We searched PubMed and EMBASE using fatigue as a major Medical subject headings (MeSH) heading with each individual disease added as a search term followed by each biological mechanism. We included only primary research articles published in English between 1996 and 2016 describing studies conducted in adult humans. We identified 26 relevant articles. While there is some evidence that the biological mechanisms causing fatigue in cancer are also associated with fatigue in other chronic illnesses, more research is needed to explore inflammation, the HPA axis, and the autonomic nervous system, and other mechanisms in relation to fatigue in a variety of chronic illnesses.

Copyright/Permission Statement

Matura, L.A., Malone, S.K., Jaime-Lara, R., Riegel, B., A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness, Biological Research for Nursing 20, no. 4: pp. 410-421. Copyright © 2018 SAGE. Reprinted by permission of SAGE Publications

Keywords

fatigue, inflammation, hypothalamic-pituitary-adrenal axis, autonomic nervous system, heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, chronic obstructive pulmonary disease

Available for download on Monday, April 01, 2019

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Date Posted: 02 November 2018

This document has been peer reviewed.