Date of this Version
Journal of Cardiac Failure
To identify those characteristics of self-management interventions in patients with heart failure (HF) that are effective in influencing health-related quality of life, mortality, and hospitalizations.
Methods and Results
Randomized trials on self-management interventions conducted between January 1985 and June 2013 were identified and individual patient data were requested for meta-analysis. Generalized mixed effects models and Cox proportional hazard models including frailty terms were used to assess the relation between characteristics of interventions and health-related outcomes. Twenty randomized trials (5624 patients) were included. Longer intervention duration reduced mortality risk (hazard ratio 0.99, 95% confidence interval [CI] 0.97–0.999 per month increase in duration), risk of HF-related hospitalization (hazard ratio 0.98, 95% CI 0.96–0.99), and HF-related hospitalization at 6 months (risk ratio 0.96, 95% CI 0.92–0.995). Although results were not consistent across outcomes, interventions comprising standardized training of interventionists, peer contact, log keeping, or goal-setting skills appeared less effective than interventions without these characteristics.
No specific program characteristics were consistently associated with better effects of self-management interventions, but longer duration seemed to improve the effect of self-management interventions on several outcomes. Future research using factorial trial designs and process evaluations is needed to understand the working mechanism of specific program characteristics of self-management interventions in HF patients.
© 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
heart failure, individual patient meta-analysis, self-management
Jonkman, N. H., Westland, H., Groenwold, R. H., Âgren, S., Anguita, M., Blue, L., Bruggink-André de la Porte, P. W., DeWalt, D. A., Hebert, P. L., Heisler, M., Jaarsma, T., Kempen, G. I., Leventhal, M. E., Lok, D. J., Mårtensson, J., Muñiz, J., Otsu, H., Peters-Klimm, F., Rich, M. W., Riegel, B., Strömberg, A., Tsuyuki, R. T., Trappenburg, J. C., Schuurmans, M. J., & Hoes, A. W. (2016). What are Effective Program Characteristics of Self-Management Interventions in Patients with Heart Failure? An Individual Patient Data Meta-Analysis. Journal of Cardiac Failure, 22 (11), 861-871. http://dx.doi.org/10.1016/j.cardfail.2016.06.422
Date Posted:31 July 2018
This document has been peer reviewed.