In many portable devices, wireless network interfaces consume upwards of 30% of scarce system energy. Reducing the transceiver’s power consumption to extend the system lifetime has therefore become a design goal. Our work is targated at this goal and is based on the following two observations. First, conventional energy management approaches have focused independently on minimizing the fixed energy cost (by shutdown) and on scalable energy costs (by leveraging, for example, the modulation, code-rate and transmission power). These two energy management approaches present a tradeoff. For example, lower modulation rates and transmission power minimize the variable energy component, but this shortens the sleep duration thereby increasing fixed energy consumption. Second, in order to meet the Quality of Service (QoS) timeliness requirements for multiple users, we need to determine to what extent each system in the network may sleep and scale. Therefore, we propose a two-phase methodology that resolves the sleep-scaling tradeoff across the physical, communications and link layers at design time and schedules nodes at runtime with near optimal energy-efficient configurations in the solution space. As a result, we are able to achieve very low run-time overheads. Our methodology is applied to a case study on delivering a guaranteed QoS for multiple users with MPEG-4 video over a slow-fading channel. By exploiting runtime controllable parameters of actual RF components and a modified 802.11 Medium Access Controller, system lifetime is increased by a factor of 3-to-10 in comparison with conventional techniques.