Date of this Version
γδ T cells contribute uniquely to host immune competence, but how they do so remain unclear. Here, by analyzing T10/T22-specific γδ T cells in mice with different T10/T22 expression patterns, we find that encountering antigen in the thymus is neither required nor inhibitory for the development of these cells. Instead, ligand recognition determines which of two distinct functional subsets γδ T cells will become. When triggered through the TCR, lymphoid-γδ T cells that encounter ligand during development produce IFNγ, while those that develop in the absence of ligand make IL-17, a major inducer of granulopoiesis during inflammation. Indeed, we find large fractions of IL-17+ γδ T cells from the draining lymph nodes immediately after peptide/CFA immunization and days before the appearance of antigen specific IL-17+ αβ T cells. This suggests a critical role for γδ T cells as ‘initial providers’ of IL-17 in an inflammatory response to novel antigens.
NOTICE: This is the author’s version of a work that was accepted for publication in Immunity. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Immunity, 29, 1, July 2008, 10.1016/j.immuni.2008.04.022.
Jensen, Kirk D. C; Su, Xiaoqin; Shin, Sunny; Li, Luke; Youssef, Sawsan; Yamasaki, Sho; Steinman, Lawrence; Saito, Takashi; Locksley, Richard M.; Davis, Mark M.; Baumgarth, Nicole; and Chien, Yueh-hsiu, "Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ" (2008). Department of Microbiology Papers. 8.
Date Posted: 09 May 2017
This document has been peer reviewed.