Master of Chemical Sciences Capstone Projects

Date of this Version

12-10-2018

Author(s)

Durpri LinFollow

Document Type

Capstone Report

Abstract

Lutein (L) and zeaxanthin (Z) are nutrients that reduce the risk of age-related macular degeneration (AMD). As micronutrients that selectively accumulate in the retina of the eye, L/Z can protect the macula from oxidative damage that contributes to AMD. This review will discuss the role of genes as a mediator between increased intake of dietary L/Z and decreased risk of AMD. Figure 1 outlines a pathway of L/Z that is subject to genetic influences, from 1) the diet to 2) the bloodstream to 3) the retina of the eye. First, L/Z are carotenoids that cannot be synthesized de novo and must be consumed from fruits and vegetables in the diet. Secondly, L/Z are transported by high-density lipoproteins (HDL) in the blood to the retina. Genetic variants that influence HDL status may impact the amount of L/Z that reaches retinal cells. Thirdly, L is taken up by retinal cells. Intracellularly, L down-regulates the expression of proinflammatory genes that contribute to the development of advanced AMD. Overall, L/Z are carotenoids in the diet that are transported by HDL and affect inflammatory pathways in AMD. The intersection of dietary L/Z, genes, and AMD will be reviewed using exemplary epidemiological, genome-wide association, and in vitro studies. The literature will support the integration of personalized nutrition, or dietary recommendations based on genomic information, into the field of eye care.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Share

COinS
 

Date Posted:11 December 2018