Canine Multifocal Retinopathy in the Australian Shepherd: A Case Report

Loading...
Thumbnail Image
Penn collection
Departmental Papers (Vet)
Degree type
Discipline
Subject
Australian Shepherd
BEST1
canine multifocal retinopathy
cmr1
multifocal retinal detachments
optical coherence tomography
Animal Diseases
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Eye Diseases
Medical Genetics
Medical Immunology
Ophthalmology
Veterinary Medicine
Funder
Grant number
License
Copyright date
Distributor
Related resources
Author
Hoffmann, Ingo
Mardin, Christian Y
Contributor
Abstract

A 1-year-old Australian Shepherd (AS) was presented for a routine hereditary eye examination. During the examination multiple raised, brown to orange lesions were noted in the fundus, which could not be attributed to a known retinal disease in this breed. As they clinically most closely resembled canine multifocal retinopathy (cmr) and no indication of an acquired condition was found, genetic tests for BEST1 gene mutations were performed. These showed the dog to be homozygous for the cmr1 (C73T/R25X) gene defect. Furthermore, ultrasound (US), electroretinography (ERG), and optical coherence tomography were performed, confirming changes typical for cmr. Subsequently, the AS pedigree members were genetically and clinically tested, demonstrating autosomal recessive inheritance with no clinical symptoms in carrier animals, as was previously described for cmr. To our knowledge, this is the first reported case of canine multifocal retinopathy in the AS breed. Further investigations are under way.

Advisor
Date Range for Data Collection (Start Date)
Date Range for Data Collection (End Date)
Digital Object Identifier
Series name and number
Publication date
2012-09-01
Journal title
Veterinary Opthalmology
Volume number
Issue number
Publisher
Publisher DOI
Journal Issue
Comments
Recommended citation
Collection