Institute for Medicine and Engineering Papers
Papers from 2007
Notch Signaling in Cancer, Eric J. Allenspach, Ivan Maillard, Jon C. Aster, and Warren Pear
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays, Michael C. Myers, Andrew D. Napper, Nuzhat Motlekar, Parag P. Shah, Chun-Hao Chiu, Mary Pat Beavers, Scott L. Diamond, Donna M. Huryn, and Amos B. Smith III
Papers from 2006
Interaction of the Gelsolin-Derived Antibacterial PBP 10 Peptide with Lipid Bilayers and Cell Membranes, Robert Bucki and Paul Janmey
Counterion-Mediated Attraction and Kinks on Loops of Semiflexible Polyelectrolyte Bundles, A. Cebers, Z. Dogic, and Paul Janmey
Regulation and Function of Tenascin-C in Heart Valve Homeostasis, Anand Kalola
The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor, Ivan Maillard, LiLi Tu, Arivazhagan Sambandam, Yumi Yashiro-Ohtani, John Millholland, Karen Keeshan, Olga Shestova, Lanwei Xu, Avinash Bhandoola, and Warren S. Pear
Impaired Notch Signaling Promotes De novo Squamous Cell Carcinoma Formation, Aaron Proweller, Lili Tu, John J. Lepore, Lan Cheng, Min Min Lu, John J. Seykora, Sarah E. Millar, Warren S. Pear, and Michael S. Parmacek
A Silicon Retina that Reproduces Signals in the Optic Nerve, Kareem A. Zaghloul and Kwabena Boahen
Papers from 2005
Separate Functions of Gelsolin Mediate Sequential Steps of Collagen Phagocytosis, P. D. Arora, M.W. C. Chan, R. A. Anderson, Paul A. Janmey, and C. A. McCulloch
Hypoxia-inducible Factor Regulates αvß3 Integrin Cell Surface Expression, Karen D. Cowden Dahl, Sarah E. Robertson, Valerie M. Weaver, and M. Celeste Simon
Power-Law Rheology of Isolated Nuclei with Deformation Mapping of Nuclear Substructures, Kris Dahl, Adam J. Engler, J. David Pajerowski, and Dennis E. Discher
Neutrophil-bead collision assay: Pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime, Kathryn E. Edmondson, William S. Denney, and Scott L. Diamond
Phosphatidylinositol-4,5 Bisphosphate Produced by PIP5K(gamma) Regulates Gelsolin, Actin Assembly, and Adhesion Strength of N-Cadherin Junctions, T. Y. El Sayegh, P. D. Arora, K. Ling, C. Laschinger, Paul Janmey, R. A. Anderson, and C. A. McCulloch
Indentation and adhesive probing of a cell membrane with AFM: Theoretical model and experiments, Shamik Sen, Shyamsundar Subramanian, and Dennis E. Discher
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells, Kareem A. Zaghloul, Kwabena A. Boahen, and Jonathan B. Demb
Competitive Hybridization Kinetics Reveals Unexpected Behavior Patterns, Ying Zhang, Daniel A. Hammer, and David J. Graves
Papers from 2004
Antibacterial Activities of Rhodamine B-Conjugated Gelsolin-Derived Peptides Compared to Those of the Antimicrobial Peptides Cathelicidin LL37, Magainin II, and Melittin, Robert Bucki, Jennifer J. Pastore, Paramjeet Randhawa, Rolands Vegners, Daniel J. Wiener, and Paul Janmey
Cholesterol Depletion Increases Membrane Stiffness of Aortic Endothelial Cells, Fitzroy H. Byfield, Helim Aranda-Espinoza, Victor G. Romanenko, George H. Rothblat, and Irena Levitan
Elongation and Fluctuations of Semi-flexible Polymers in a Nematic Solvent, Z. Dogic, J. Zhang, A. W.C. Lau, Helim Aranda-Espinoza, Paul M. Dalhaimer, Dennis E. Discher, Paul Janmey, Randall Kamien, Thomas C. Lubensky, and Arjun Yodh
Myotubes differentiate optimally on substrates with tissue-like stiffness : pathological implications for soft or stiff microenvironments, Adam J. Engler, Maureen A. Griffin, Shamik Sen, Carsten G. Bönnemann, H. Lee Sweeney, and Dennis E. Discher
Biopolymer Networks and Cellular Mechanosensing, Penelope Georges, Oliver Wagner, Tony Yeung, and Paul Janmey
Topographical Pattern Dynamics in Passive Adhesion of Cell Membranes, Alina Hategan, Kheya Sengupta, Samuel Kahn, Erich Sackmann, and Dennis E. Discher
Neutrophil String Formation: Hydrodynamic Thresholding and Cellular Deformation during Cell Collisions, K. E. Kadash, M. B. Lawrence, and Scott L. Diamond
Role of lateral cell–cell border location and extracellular/transmembrane domains in PECAM/CD31 mechanosensation, David A. Kaufman, Steven M. Albelda, Jing Sun, and Peter F. Davies
Sensitivity of Volume-regulated Anion Current to Cholesterol Structural Analogues, Victor G. Romanenko, George H. Rothblat, and Irena Levitan
The Interaction of Neurofilaments with the Microtubule Motor Cytoplasmic Dynein, Oliver I. Wagner, Jennifer Ascaño, Mariko Tokito, Jean-Francois Leterrier, Paul Janmey, and Erika Holzbaur
Optic Nerve Signals in a Neuromorphic Chip II: Testing and Results, Kareem A. Zaghloul and Kwabena A. Boahen
Optic Nerve Signals in a Neuromorphic Chip I: Outer and Inner Retina Models, Kareem A. Zaghloul and Kwabena A. Boahen
Papers from 2003
Pore Stability and Dynamics in Polymer Membranes, Harry Bermudez, Helim Aranda-Espinoza, Daniel A. Hammer, and Dennis E. Discher
The State Diagram for Cell Adhesion Mediated by Two Receptors, Sujata K. Bhatia, Michael R. King, and Daniel A. Hammer
Interplay between Rolling and Firm Adhesion Elucidated with a Cell-Free System Engineered with Two Distinct Receptor-Ligand Pairs, A. Omolola Eniola, P. Jeanene Willcox, and Daniel A. Hammer
Adhesively-Tensed Cell Membranes: Lysis Kinetics and Atomic Force Microscopy Probing, Alina Hategan, Richard Law, Samuel Kahn, and Dennis E. Discher
Imaging Live Cells Under Mechanical Stress, Brian P. Helmke and Peter F. Davies
Mapping Mechanical Strain of an Endogenous Cytoskeletal Network in Living Endothelial Cells, Brian P. Helmke, Amy B. Rosen, and Peter F. Davies
Kinetics of random aggregation-fragmentation processes with multiple components, Ian J. Laurenzi and Scott L. Diamond
Cooperativity in Forced Unfolding of Tandem Spectrin Repeats, Richard Law, Philippe Carl, Sandy Harper, Paul M. Dalhaimer, David W. Speicher, and Dennis E. Discher
Pathway Shifts and Thermal Softening in Temperature-Coupled Forced Unfolding of Spectrin Domains, Richard Law, George Liao, Sandy Harper, Guoliang Yang, David W. Speicher, and Dennis E. Discher
α6ß4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of α3ß1 integrin, Alan J. Russell, Edgar F. Fincher, Linda Millman, Robyn Smith, Veronica Vela, Elizabeth A. Waterman, Clara N. Dey, Shireen Guide, Valerie M. Weaver, and Matthew P. Marinkovich
Networks with fourfold connectivity in two dimensions, Frédéric Tessier, David H. Boal, and Dennis E. Discher
Mechanisms of Mitochondria–Neurofilament Interactions, Oliver I. Wagner, Jonathan Lifshitz, Paul A. Janmey, M. Linden, T. K. McIntosh, and Jean-François Leterrier
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling, Andrew P. Weng, Yusun Nam, Michael S. Wolfe, Warren S. Pear, James D. Griffin, Stephen C. Blacklow, and Jon C. Aster
Lamellar Phase of Stacked Two-Dimensional Rafts of Actin Filaments, Gerard C.L. Wong, Alison Lin, Jay X. Tang, Youli Li, Paul Janmey, and Cyrus R. Safinya
Autocrine laminin-5 ligates {alpha}6{beta}4 integrin and activates RAC and NF{kappa}B to mediate anchorange-independent survival of mammary tumors, Nastaran Zahir, Johnathon N. Lakins, Alan Russell, WenYu Ming, Chandrima Chatterjee, Gabriela I. Rozenberg, Matthew P. Marinkovich, and Valerie M. Weaver
Papers from 2002
Domain unfolding in neurofilament sidearms: effects of phosphorylation and ATP, Helim Aranda-Espinoza, Philippe Carl, Jean-François Leterrier, Paul Janmey, and Dennis E. Discher
Rolling Adhesion of Yeast Engineered to Express Cell Adhesion Molecules, Sujata K. Bhatia, Jeffrey S. Swers, Raymond T. Camphausen, K. Dane Wittrup, and Daniel A. Hammer
The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis, Peter F. Davies, Denise C. Polacek, Congzhu Shi, and Brian P. Helmke
Selectin-Like Kinetics and Biomechanics Promote Rapid Platelet Adhesion in Flow: The GPIbalpha-vWF Tether Bond, Teresa A. Doggett, Gaurav Girdhar, Avril Lawshé, David W. Schmidtke, Ian J. Laurenzi, Scott L. Diamond, and Thomas G. Diacovo
The Cytoskeleton Under External Fluid Mechanical Forces: Hemodynamic Forces Acting on the Endothelium, Brian P. Helmke and Peter F. Davies
Modulation of Endothelial Inward-Rectifier K+ Current by Optical Isomers of Cholesterol, Victor G. Romanenko, George H. Rothblat, and Irena Levitan
Metal Ion-Induced Lateral Aggregation of Filamentous Viruses fd and M13, Jay X. Tang, Paul Janmey, Alexander Lyubartsev, and Lars Nordenskiöld
Peering from the outside in: viscoelastic properties of the extracellular matrix dictate spatial organization and apoptosis resistance in mammary epithelial cells, N. Zahir, T. Yeung, W. Ming, Paul Janmey, and Valerie M. Weaver
Papers from 2001
Electromechanical Limits of Polymersomes, Helim Aranda-Espinoza, Harry Bermudez, Frank S. Bates, and Dennis E. Discher
Signal-to-noise measurements utilizing a novel dual-energy multimedia detector, G. C. Giakos, S. Chowdhury, N. Shah, Srinivasan Vedantham, A. G. Passerini, Sankararaman Suryanarayanan, R. Nemer, K. Mehta, N. Patnekar, S. Sumrain, K. Nataraj, and Christian Scheiber
Papers from 1999
Electrostatic Repulsion of Positively Charged Vesicles and Negatively Charged Objects, Helim Aranda-Espinoza, Yi Chen, Nily Dan, Thomas C. Lubensky, Philip Nelson, Laurence Ramos, and David A. Weitz