Penn Arts & Sciences

The University of Pennsylvania School of Arts and Sciences forms the foundation of the scholarly excellence that has established Penn as one of the world's leading research universities. We teach students across all 12 Penn schools, and our academic departments span the reach from anthropology and biology to sociology and South Asian studies.

Members of the Penn Arts & Sciences faculty are leaders in creating new knowledge in their disciplines and are engaged in nearly every area of interdisciplinary innovation. They are regularly recognized with academia's highest honors, including membership in prestigious societies like the National Academy of Sciences, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, and the American Philosophical Society, as well as significant prizes such as MacArthur and Guggenheim Fellowships.

The educational experience offered by Penn Arts & Sciences is likewise recognized for its excellence. The School's three educational divisions fulfill different missions, united by a broader commitment to providing our students with an unrivaled education in the liberal arts. The College of Arts and Sciences is the academic home of the majority of Penn undergraduates and provides 60 percent of the courses taken by students in Penn's undergraduate professional schools. The Graduate Division offers doctoral training to over 1,300 candidates in more than 30 graduate programs. And the College of Liberal and Professional Studies provides a range of educational opportunities for lifelong learners and working professionals.

 

 

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  • Publication
    Announcements
    (1980)
  • Publication
    Reverse-Polarity Activity-Based Protein Profiling
    (2019-05-01) Dettling, Suzanne
    Reverse-polarity activity-based protein profiling (RP-ABPP) is a chemical proteomics approach that uses clickable, nucleophilic hydrazine probes to capture and identify protein-bound electrophiles in cells. The RP-ABPP approach is used to characterize the structure and function of reactive electrophilic PTMs and the proteins that harbor them, which may uncover unknown or novel functions of proteins in an endogenous setting. RP-ABPP has demonstrated utility as a versatile method to monitor metabolic regulation of electrophilic cofactors, as was done with the pyruvoyl cofactor in S-adenosyl-L- methionine decarboxylase (AMD1) and discover novel types of electrophilic modifications on proteins in human cells, as was done with the glyoxylyl modification on secernin-3 (SCRN3). These cofactors cannot be predicted by sequence and as such this area is relatively undeveloped. RP-ABPP is the only global unbiased approach to discover these electrophiles. Here, the utility of these experiments is described and a detailed protocol is provided for de novo discovery, quantitation, and global profiling of electrophilic functionality of proteins through the use of nitrogenous nucleophilic probes deployed directly to living cells in culture.
  • Publication
    Announcements
    (2006-01-01)
  • Publication
    Recent Dissertations
    (1995)
  • Publication
    Visualizing Native People in Philadelphia's Museums: Public Views and Student Reviews
    (2018-01-17) Bruchac, Margaret
    Material representations of Indigenous history in public museums do more than merely present the past. Exhibitions are always incomplete and idiosyncratic, revealing only a small window into the social worlds of diverse human communities. Museums create, in essence, staged assemblages: compositions of objects, documents, portraits, and other material things that have been filtered through an array of influences. These influences—museological missions, collection processses, curatorial choices, loan possibilities, design concepts, research specialties, funding options, consultant opinions, space limitations, time limits, logistical challenges, etc.—will be unique for each museum and each collection. Taken together, they will inevitably determine which objects are selected for display, what events will take precedence, how cultural interactions will be re-conceptualized, and whose stories will be told.
  • Publication
  • Publication
    The Influence of Alkali and Alkaline Earth Metals on Transition-metal Catalyzed Reactions
    (2018-05-17) Qi, Jia
    Alkali and alkaline earth metals are useful co-catalysts in many inorganic and organometallic reactions. The interactions of these metals to transition-metal complexes modulate the overall structures. The alkali and alkaline earth metal ions withdraw electron density from transition metal center and tune the reduction potentials. The stabilization of anion intermediates by alkali and alkaline earth metal ions reduces transition-state energy and enhance the reactivity kinetically. In homogeneous catalysis, alkali and alkaline earth metals have been shown to bind to electron-rich anionic ligands that then stabilize the formation of heterobimetallic complexes. This is especially important when key transition states are stabilized by such coordination as this can lead to greatly enhanced catalytic efficiency. These metal ions can also collaboratively bind to crown-ether installed ligands and control metal-ligand cooperativity. In addition, reaction selectivity could also be enhanced by using different sizes of alkali or alkaline earth metal ions. Thus, incorporation of alkali and alkaline earth metals to transition-metal catalysts can modulate or completely change the reactivity.
  • Publication
    News and Notes
    (1973)
  • Publication
    Three Anglo-Jewish Portraits and Their Legacy for Today: Moses Marcus, the Convert; Abraham Tang, the Radical Maskil; David Levi, the Defender of Judaism
    (2007-01-01) Ruderman, David B
    My fascination with Anglo-Jewish history emerged by chance, but has been profound enough for me to write two books on the subject. My appreciation of the richness, diversity and significance of the history of Jewish cultural history on English soil continues to grow and deepen. There is a long tradition of Jewish historical writing, exemplified by the work of the Jewish Historical Society of England. But modern historians have barely begun to take pre-twentieth century Anglo-Jewish history seriously. The drama of modernity seems still to be regarded as a German story, beginning with Mendelssohn and continuing into Eastern Europe. Historians such as Todd Engelman and David Katz have made major contributions to our subject, but in so doing have sometimes revealed their own biases.
  • Publication
    Conference Announcement
    (2010-01-01)