Greater Omentectomy Improves Insulin Sensitivity in Nonobese Dogs

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dc.contributor.authorLottati, Maya
dc.contributor.authorKolka, Cathryn M
dc.contributor.authorStefanovski, Darko
dc.contributor.authorStefanovski, Darko
dc.contributor.authorKirkman, Erlinda L
dc.contributor.authorBergman, Richard N
dc.date2023-05-17T11:08:00.000
dc.date.accessioned2023-05-23T04:44:40Z
dc.date.available2023-05-23T04:44:40Z
dc.date.issued2012-09-06
dc.date.submitted2015-02-06T10:43:54-08:00
dc.description.abstractVisceral adiposity is strongly associated with insulin resistance; however, little evidence directly demonstrates that visceral fat per se impairs insulin action. Here, we examine the effects of the surgical removal of the greater omentum and its occupying visceral fat, an omentectomy (OM), on insulin sensitivity (SI) and β-cell function in nonobese dogs. Thirteen male mongrel dogs were used in this research study; animals were randomly assigned to surgical treatment with either OM (n = 7), or sham-surgery (SHAM) (n = 6). OM failed to generate measurable changes in body weight (+2%; P = 0.1), or subcutaneous adiposity (+3%; P = 0.83) as assessed by magnetic resonance imaging (MRI). The removal of the greater omentum did not significantly reduce total visceral adipose volume (−7.3 ± 6.4%; P = 0.29); although primary analysis showed a trend for OM to increase SI when compared to sham operated animals (P = 0.078), further statistical analysis revealed that this minor reduction in visceral fat alleviated insulin resistance by augmenting SI of the periphery (+67.7 ± 35.2%; P = 0.03), as determined by the euglycemic-hyperinsulinemic clamp. Insulin secretory response during the hyperglycemic step clamp was not directly influenced by omental fat removal (presurgery 6.82 ± 1.4 vs. postsurgery: 6.7 ± 1.2 pmol/l/mg/dl, P = 0.9). These findings provide new evidence for the deleterious role of visceral fat in insulin resistance, and suggest that a greater OM procedure may effectively improve insulin sensitivity.
dc.description.commentsAt the time of publication, author Darko Stefanovski was affiliated with the Keck School of Medicine at the University of Southern California. Currently, he is a faculty member at the University of Pennsylvania's School of Veterinary Medicine.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/48897
dc.legacy.articleid1101
dc.legacy.fields10.1038/oby.2008.642
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1101&context=vet_papers&unstamped=1
dc.rights<p>This is the accepted version of the article which has been published in final form at <a href="http://dx.doi.org/10.1038/oby.2008.642">dx.doi.org/10.1038/oby.2008.642</a></p>
dc.source.beginpage674
dc.source.endpage680
dc.source.issue136
dc.source.issue4
dc.source.journalDepartmental Papers (Vet)
dc.source.journaltitleObesity: A Research Journal
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume17
dc.subject.otherMedical Sciences
dc.titleGreater Omentectomy Improves Insulin Sensitivity in Nonobese Dogs
dc.typeArticle
digcom.contributor.authorLottati, Maya
digcom.contributor.authorKolka, Cathryn M
digcom.contributor.authorisAuthorOfPublication|email:sdarko@vet.upenn.edu|institution:University of Pennsylvania|Stefanovski, Darko
digcom.contributor.authorKirkman, Erlinda L
digcom.contributor.authorBergman, Richard N
digcom.identifiervet_papers/136
digcom.identifier.contextkey6618594
digcom.identifier.submissionpathvet_papers/136
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublication6f18de03-4ea6-4da8-b38a-5cb00310137e
relation.isAuthorOfPublication6f18de03-4ea6-4da8-b38a-5cb00310137e
relation.isAuthorOfPublication.latestForDiscovery6f18de03-4ea6-4da8-b38a-5cb00310137e
upenn.schoolDepartmentCenterDepartmental Papers (Vet)
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