Incomplete Lineage Sorting: Consistent Phylogeny Estimation From Multiple Loci

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Statistics Papers
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bioinformatics
estimation theory
genetics
stochastic processes
estimation errors
incomplete lineage sorting
multiple gene trees
multiple loci
phylogeny estimation
stochastic assumptions
biology and genetics
incomplete lineage sorting
probability and statistics
coalescent process
phylogenetics
population genetics
statistical consistency
topological concordance
algorithms
animals
chromosome mapping
computer simulation
evolution
humans
linkage
disequilibrium
models
Computer Sciences
Genetics and Genomics
Physical Sciences and Mathematics
Statistics and Probability
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Mossel, Elchanan
Roch, Sébastien
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Abstract

We introduce a simple computationally efficient algorithm for reconstructing phylogenies from multiple gene trees in the presence of incomplete lineage sorting, that is, when the topology of the gene trees may differ from that of the species tree. We show that our technique is statistically consistent under standard stochastic assumptions, that is, it returns the correct tree given sufficiently many unlinked loci. We also show that it can tolerate moderate estimation errors.

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2010-01-01
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IEEE/ACM Transactions on Computational Biology and Bioinformatics
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