Objective: This clinical report describes and illustrates step-by-step protocols for interdisciplinary esthetic treatment with current digital and microscopic tools. Clinical Considerations: Digital dentistry is no longer limited to impression making and restoration fabrication but starts already in the diagnostic and treatment planning phase. In particular, digital smile design tools have significantly improved clinical and laboratory workflows, allowing for natural and facially driven smiles, based on the patient's specific needs and preferences. Digital technologies also facilitate high precision and accuracy in the laboratory, which are interconnected with the quality of the clinical care. Precision and minimally invasive dentistry require visual magnification aids through high-power loupes or, even better, surgical microscopes. For optimal clinical success, however, these tools must be integrated into efficient workflows and made part of a comprehensive clinical and laboratory concept. Conclusions: Digital and high-magnification tools in clinics and dental laboratories facilitate highly esthetic and precise outcomes when integrated into a comprehensive treatment concept. Clinical Significance: While a plethora of new tools and technologies is available for the dental laboratory and clinical practice, they can be daunting. Clear step-by-step workflows and protocols must be followed to apply them in a most efficient and effective manner for optimal outcomes. © 2022 Wiley Periodicals LLC.