Objective: To explore the synergy between population health and public health by initiating a discourse about their interconnected roles, responsibilities, and approaches in achieving optimal health outcomes. Overview: Population health and public health, although distinct, are interconnected disciplines critical for enhancing health outcomes. Population health focuses on analyzing health determinants and outcomes within specific groups, employing data to guide targeted interventions and policies. Public health, on the other hand, prioritizes broader preventive measures and community-wide interventions to safeguard health. Both fields benefit from a transdisciplinary approach that integrates strategies to address and improve health. Such integration is essential for addressing health disparities and improving the efficiency of health systems. By combining the analytical strengths of population health with the implementation capabilities of public health, a more comprehensive framework can be developed. These collaborations will not only enhance the effectiveness of health programs but also promote health equity by leveraging collective expertise and resources. They will facilitate the development of interventions that are both preventive and responsive, capable of addressing the upstream determinants of health and the immediate needs of communities. Such transdisciplinary efforts were demonstrated within the oral health field during the COVID-19 pandemic. Conclusions: The synergy between population and public health can lead to robust health outcomes, fostering comprehensive health promotion and disease prevention strategies. By aligning research, practices, and policies, these integrated approaches will transcend traditional boundaries within the healthcare sector to build efficient health systems. © 2024 The Author(s).