Adhesive Dynamics Simulation of Neutrophil Arrest with Deterministic Activation

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dc.contributor.authorKrasik, Ellen F
dc.contributor.authorYee, Ka Lai
dc.contributor.authorHammer, Daniel A
dc.date2023-05-17T02:06:48.000
dc.date.accessioned2023-05-22T12:08:13Z
dc.date.available2023-05-22T12:08:13Z
dc.date.issued2006-08-01
dc.date.submitted2008-04-03T09:29:27-07:00
dc.description.abstractThe transition from rolling to firm adhesion is a key element of neutrophil activation and essential to the inflammatory response. Although the molecular mediators of rolling and firm adhesion are known to be selectins and ß2-integrins, respectively, the precise dynamic mechanism by which these ligands facilitate neutrophil arrest remains unknown. Recently, it has been shown that ligation of E-selectin can stimulate the firm adhesion of neutrophils via a MAP-kinase cascade. To study the possible mechanism by which neutrophil arrest could occur, we created an integrated model by combining two methodologies from computational biology: a mechanics-based modeling of leukocyte adhesion (adhesive dynamics) and signal transduction pathway modeling. Within adhesive dynamics, a computational method our group has shown to accurately recreate rolling dynamics, we include a generic, tunable integrin activation module that links selectin engagement to integrin and activity. This model allows us to relate properties of the activation function to the dynamics of rolling and the time and distance rolled before arrest. This integrated model allows us to understand how intracellular signaling activity can set the timescale of neutrophil activation, adhesion, and diapedesis.
dc.description.commentsReprinted from Biophysical Journal, Volume 91, Issue 4, August 2006, pages 1145-1155. Publisher URL: http://dx.doi.org/10.1529/biophysj.105.070706
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/2775
dc.legacy.articleid1127
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1127&context=be_papers&unstamped=1
dc.source.issue109
dc.source.journalDepartmental Papers (BE)
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.titleAdhesive Dynamics Simulation of Neutrophil Arrest with Deterministic Activation
dc.typeArticle
digcom.identifierbe_papers/109
digcom.identifier.contextkey480693
digcom.identifier.submissionpathbe_papers/109
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublicationcce6c6bd-9715-4e4e-8385-d5db2715b062
relation.isAuthorOfPublicationcce6c6bd-9715-4e4e-8385-d5db2715b062
relation.isAuthorOfPublication.latestForDiscoverycce6c6bd-9715-4e4e-8385-d5db2715b062
upenn.schoolDepartmentCenterDepartmental Papers (BE)
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