Components of Metabolic Syndrome and 5-Year Chance in Insulin Clearance - The Resistance Atherosclerosis Study (IRAS)

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dc.contributor.authorLee, C. Christine
dc.contributor.authorLorenzo, Carlos
dc.contributor.authorHaffner, Steven M
dc.contributor.authorWagenknecht, Lynne E
dc.contributor.authorGoodarzi, Mark O
dc.contributor.authorStefanovski, Darko
dc.contributor.authorNorris, Jill M
dc.contributor.authorRewers, Marian J
dc.contributor.authorHanley, Anthony J
dc.date2023-05-17T11:07:26.000
dc.date.accessioned2023-05-23T04:44:41Z
dc.date.available2023-05-23T04:44:41Z
dc.date.issued2013-05-15
dc.date.submitted2015-02-04T07:43:49-08:00
dc.description.abstractAims Cross-sectional evidence indicates that abdominal adiposity, hypertension, dyslipidaemia and glycaemia are associated with reduced metabolic clearance rate of insulin (MCRI). Little is known about the progression of MCRI and whether components of metabolic syndrome are associated with the change in MCRI. In this study, we examined the association between components of metabolic syndrome and the 5-year change of MCRI. Methods At baseline and 5-year follow-up, we measured fasting plasma triglycerides (TG), high-density lipoprotein (HDL) cholesterol, blood pressure (BP), waist circumference (WC) and fasting blood glucose (FBG) in 784 non-diabetic participants in the Insulin Resistance Atherosclerosis Study. MCRI, insulin sensitivity (SI) and acute insulin response (AIR) were determined from frequently sampled intravenous glucose tolerance tests. Results We observed a 29% decline of MCRI at follow-up. TG, systolic BP and WC at baseline were inversely associated with a decline of MCRI regression models adjusted for age, sex, ethnicity, smoking, alcohol consumption, energy expenditure, family history of diabetes, BMI, SI and AIR [β = −0.057 (95% confidence interval, CI: −0.11, −0.0084) for TG, β = −0.0019 (95% CI: −0.0035, −0.00023) for systolic BP and β  = −0.0084 (95% CI: −0.013, −0.0039) for WC; all p < 0.05]. Higher HDL cholesterol at baseline was associated with an increase in MCRI [multivariable-adjusted β = 0.0029 (95% CI: 0.0010, 0.0048), p = 0.002]. FBG at baseline was not associated with MCRI at follow-up [multivariable-adjusted β = 0.0014 (95% CI: −0.0026, 0.0029)]. Conclusions MCRI declined progressively over 5 years in a non-diabetic cohort. Components of metabolic syndrome at baseline were associated with a significant change in MCRI.
dc.description.commentsAt the time of publication, author Darko Stefanovski was affiliated with the Cedars Sinai Medical Center. Currently, he is a faculty member at the University of Pennsylvania's School of Veterinary Medicine.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/48899
dc.legacy.articleid1099
dc.legacy.fields10.1111/dom.12049
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1099&amp;context=vet_papers&amp;unstamped=1
dc.rightsThis is the accepted version of the article which has been published in final form at http://dx.doi.org/10.1111/dom.12049
dc.source.beginpage441
dc.source.endpage447
dc.source.issue138
dc.source.issue5
dc.source.journalDepartmental Papers (Vet)
dc.source.journaltitleDiabetes, Obesity and Metabolism
dc.source.statuspublished
dc.source.volume15
dc.subject.otherbody composition; dyslipidaemia; hypertension; insulin resistance; observational study
dc.subject.otherBiochemical Phenomena, Metabolism, and Nutrition
dc.subject.otherEndocrinology, Diabetes, and Metabolism
dc.subject.otherNutritional and Metabolic Diseases
dc.titleComponents of Metabolic Syndrome and 5-Year Chance in Insulin Clearance - The Resistance Atherosclerosis Study (IRAS)
dc.typeArticle
digcom.identifiervet_papers/138
digcom.identifier.contextkey6605559
digcom.identifier.submissionpathvet_papers/138
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublication6f18de03-4ea6-4da8-b38a-5cb00310137e
relation.isAuthorOfPublication6f18de03-4ea6-4da8-b38a-5cb00310137e
relation.isAuthorOfPublication.latestForDiscovery6f18de03-4ea6-4da8-b38a-5cb00310137e
upenn.schoolDepartmentCenterDepartmental Papers (Vet)
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