Temporal lobe epilepsy (TLE) is characterized by the presence of recurrent focal seizures and structural brain abnormalities, most notably hippocampal atrophy. However, the extent of hemispheric asymmetry of cortical gray matter remains uncertain. Here, 125 participants (healthy controls and epilepsy) were harmonized into a BIDS-compliant 7T MRI dataset consisting of anatomical, functional, and field map modalities. Medial temporal and cortical region segmentation was performed automatically using ASHS and fMRIPrep pipelines. Eight gray matter volumes of cortical regions were normalized proportionally and allometrically for intracranial volume (ICV). Ipsilateral and contralateral hemispheres were contrasted within left- and right-onset TLE cohorts compared with controls using independent-samples t-tests. Significant ipsilateral gray matter reductions were in Inferior Parietal (p = 0.041) and subthreshold trends in Superior and Middle Temporal regions for left-onset TLE. These findings provide evidence of focal cortical atrophy patterns consistent with lateralization of seizure onset. Verification with larger samples and multimodal correlation is required to enhance volumetric biomarkers for clinical TLE lateralization.