GENETIC APPROACH TO THE STUDY OF EPIDEMIOLOGY AND PATHOGENESIS OF ACTINOBACILLUS ACTINOMYCETEMCOA4ITANS IN LOCALIZED JUVENILE PERIODONTITIS

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dc.contributor.authorDiRienzo, J. M.
dc.contributor.authorSlots, J.
dc.date2023-05-18T00:28:10.000
dc.date.accessioned2023-05-22T13:12:48Z
dc.date.available2023-05-22T13:12:48Z
dc.date.issued2013-01-03
dc.date.submitted2021-03-15T11:24:06-07:00
dc.description.abstractActinobacillus acrinomycetemcomirans isolates from periodontal pockets were examined for restriction fragment-length polymorphism using a characterized 4.7-kb DNA probe. A total of 6 patterns of RFLP was found in 133 isolates originating from 12 subjects. No relatedness was found between RFLP types and serotypes. Different periodontal sites within the same subject and different individuals within the same family sometimes showed only one type of A. actinomycetemcomitans RFLP. When members among the same family showed 2 RFLP types, children were always infected with the A. acfinomycefemcomitans strains found in at least one of the parents. These findings support the concept of familial spread of A. actinomycetemcomitans. A. actinomycetemcomitans RFLP type B, corresponding to reference strain JP2, seems to be particularly virulent, as indicated from the presence of RFLP type B in 3 subjects who converted from a healthy periodontal state to localized juvenile periodontitis. RFLP type B was not detected in any of the 21 A. acrinomycetemcomitans-infected patients with adult periodontitis. The RFLP method seems to be useful in determining the epidemiology and possibly the potential virulence of periodontal strains of A. actinomycetemcomitans.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/8847
dc.legacy.articleid1296
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1296&context=dental_papers&unstamped=1
dc.rights© <2013>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.beginpage79S
dc.source.endpage84S
dc.source.issue140
dc.source.issueSuppl
dc.source.journalDepartmental Papers (Dental)
dc.source.journaltitleArchives of Oral Biology
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume35
dc.subject.otherjuvenile periodontitis
dc.subject.otherepidemiology
dc.subject.othervirulence
dc.subject.otherrestriction fragment-length polymorphism
dc.subject.otherDNA probes
dc.subject.otherActinobaccillus actinomycetemcomitans
dc.subject.otherDentistry
dc.titleGENETIC APPROACH TO THE STUDY OF EPIDEMIOLOGY AND PATHOGENESIS OF ACTINOBACILLUS ACTINOMYCETEMCOA4ITANS IN LOCALIZED JUVENILE PERIODONTITIS
dc.typeArticle
digcom.contributor.authorDiRienzo, J. M.
digcom.contributor.authorSlots, J.
digcom.identifierdental_papers/140
digcom.identifier.contextkey22062712
digcom.identifier.submissionpathdental_papers/140
digcom.typearticle
dspace.entity.typePublication
upenn.schoolDepartmentCenterDepartmental Papers (Dental)
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