The Pathology of the Feline Model of Mucopolysaccharidosis I

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Departmental Papers (Vet)
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Comparative and Laboratory Animal Medicine
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Medicine and Health Sciences
Veterinary Medicine
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Aguirre, Gustavo D
Jezyk, Peter F
Desnick, Robert J
Patterson, Donald F
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Abstract

Five cats with feline α-L-iduronidase-deficient mucopolysaccharidosis were studied. Membrane-bound cytoplasmic inclusions were present in central nervous system neurons, hepatocytes, chondrocytes, vascular and splenic smooth muscle cells, bone marrow leukocytes, and fibroblasts of the skin, eye, and cardiac valves. The lesions in these cats closely resemble those described in human patients with mucopolysaccharidosis I H (Hurler syndrome).

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1983-07-01
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American Journal of Pathology
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PMCID: PMC1916323
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