Overexpression of SERCA1a in the mdx Diaphragm Reduces Susceptibility to Contraction-Induced Damage

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dc.contributor.authorSleeper, Margaret M
dc.contributor.authorBarton, Elisabeth R
dc.contributor.authorMorine, Kevin J
dc.contributor.authorSweeney, H. Lee
dc.date2023-05-17T07:54:28.000
dc.date.accessioned2023-05-23T04:45:54Z
dc.date.available2023-05-23T04:45:54Z
dc.date.issued2010-12-10
dc.date.submitted2013-07-24T11:53:43-07:00
dc.description.abstractAlthough the precise pathophysiological mechanism of muscle damage in dystrophin-deficient muscle remains disputed, calcium appears to be a critical mediator of the dystrophic process. Duchenne muscular dystrophy patients and mouse models of dystrophin deficiency exhibit extensive abnormalities of calcium homeostasis, which we hypothesized would be mitigated by increased expression of the sarcoplasmic reticulum calcium pump. Neonatal adeno-associated virus gene transfer of sarcoplasmic reticulum ATPase 1a to the mdx diaphragm decreased centrally located nuclei and resulted in reduced susceptibility to eccentric contraction-induced damage at 6 months of age. As the diaphragm is the mouse muscle most representative of human disease, these results provide impetus for further investigation of therapeutic strategies aimed at enhanced cytosolic calcium removal.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/49011
dc.legacy.articleid1008
dc.legacy.fieldstrue
dc.legacy.fields10.1089/hum.2010.077
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1008&context=vet_papers&unstamped=1
dc.rightsThis is a copy of an article published in the Human Gene Therapy © 2010 [copyright Mary Ann Liebert, Inc.]; Human Gene Therapy is available online at: http://www.liebertonline.com.
dc.source.beginpage1735
dc.source.endpage1739
dc.source.issue9
dc.source.issue12
dc.source.journalDepartmental Papers (Vet)
dc.source.journaltitleHuman Gene Therapy
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume21
dc.subject.otherComparative and Laboratory Animal Medicine
dc.subject.otherMedicine and Health Sciences
dc.subject.otherMusculoskeletal Diseases
dc.subject.otherVeterinary Medicine
dc.titleOverexpression of SERCA1a in the mdx Diaphragm Reduces Susceptibility to Contraction-Induced Damage
dc.typeArticle
digcom.contributor.authorMorine, Kevin J
digcom.contributor.authorisAuthorOfPublication|email:sleeper@vet.upenn.edu|institution:University of Pennsylvania|Sleeper, Margaret M
digcom.contributor.authorisAuthorOfPublication|email:erbarton@biochem.dental.upenn.edu|institution:University of Pennsylvania|Barton, Elisabeth R
digcom.contributor.authorisAuthorOfPublication|email:lsweeney@mail.med.upenn.edu|institution:University of Pennsylvania|Sweeney, H. Lee
digcom.identifiervet_papers/9
digcom.identifier.contextkey4343053
digcom.identifier.submissionpathvet_papers/9
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublicationba1391f5-a1f2-456f-ad2c-db0d1076abda
relation.isAuthorOfPublicationc68585f4-a05a-4e5d-893c-4434bff8bf12
relation.isAuthorOfPublication58572a7a-9fcf-4d55-95fd-30cb7fe305ca
relation.isAuthorOfPublication.latestForDiscoveryba1391f5-a1f2-456f-ad2c-db0d1076abda
upenn.schoolDepartmentCenterDepartmental Papers (Vet)
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