Canine Multifocal Retinopathy in the Australian Shepherd: A Case Report

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dc.contributor.authorGuziewicz, Karina E
dc.contributor.authorZangerl, Barbara
dc.contributor.authorGuziewicz, Karina E
dc.contributor.authorAguirre, Gustavo D
dc.contributor.authorZangerl, Barbara
dc.contributor.authorMardin, Christian Y
dc.date2023-05-17T11:21:26.000
dc.date.accessioned2023-05-23T04:45:51Z
dc.date.available2023-05-23T04:45:51Z
dc.date.issued2012-09-01
dc.date.submitted2015-04-15T07:42:26-07:00
dc.description.abstractA 1-year-old Australian Shepherd (AS) was presented for a routine hereditary eye examination. During the examination multiple raised, brown to orange lesions were noted in the fundus, which could not be attributed to a known retinal disease in this breed. As they clinically most closely resembled canine multifocal retinopathy (cmr) and no indication of an acquired condition was found, genetic tests for BEST1 gene mutations were performed. These showed the dog to be homozygous for the cmr1 (C73T/R25X) gene defect. Furthermore, ultrasound (US), electroretinography (ERG), and optical coherence tomography were performed, confirming changes typical for cmr. Subsequently, the AS pedigree members were genetically and clinically tested, demonstrating autosomal recessive inheritance with no clinical symptoms in carrier animals, as was previously described for cmr. To our knowledge, this is the first reported case of canine multifocal retinopathy in the AS breed. Further investigations are under way.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/49005
dc.legacy.articleid1126
dc.legacy.fields10.1111/j.1463-5224.2012.01005.x
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1126&context=vet_papers&unstamped=1
dc.rights<p>This is the accepted version of the article, which has been published in final form at <a href="http://dx.doi.org/10.1111/j.1463-5224.2012.01005.x">10.1111/j.1463-5224.2012.01005.x</a>.</p>
dc.source.beginpage134
dc.source.endpage138
dc.source.issue84
dc.source.issueIssue Supplement s2
dc.source.journalDepartmental Papers (Vet)
dc.source.journaltitleVeterinary Opthalmology
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume15
dc.subject.otherAustralian Shepherd
dc.subject.otherBEST1
dc.subject.othercanine multifocal retinopathy
dc.subject.othercmr1
dc.subject.othermultifocal retinal detachments
dc.subject.otheroptical coherence tomography
dc.subject.otherAnimal Diseases
dc.subject.otherCongenital, Hereditary, and Neonatal Diseases and Abnormalities
dc.subject.otherEye Diseases
dc.subject.otherMedical Genetics
dc.subject.otherMedical Immunology
dc.subject.otherOphthalmology
dc.subject.otherVeterinary Medicine
dc.titleCanine Multifocal Retinopathy in the Australian Shepherd: A Case Report
dc.typeArticle
digcom.contributor.authorHoffmann, Ingo
digcom.contributor.authorisAuthorOfPublication|email:karinag@vet.upenn.edu|institution:University of Pennsylvania|Guziewicz, Karina E
digcom.contributor.authorisAuthorOfPublication|email:bzangerl@vet.upenn.edu|institution:University of Pennsylvania|Zangerl, Barbara
digcom.contributor.authorisAuthorOfPublication|email:gda@vet.upenn.edu|institution:University of Pennsylvania|Aguirre, Gustavo D
digcom.contributor.authorMardin, Christian Y
digcom.identifiervet_papers/84
digcom.identifier.contextkey6986604
digcom.identifier.submissionpathvet_papers/84
digcom.typearticle
dspace.entity.typePublication
person.identifier.orcid0000-0002-5228-256X
person.identifier.orcid0000-0002-5228-256X
relation.isAuthorOfPublication1a18ef39-6294-4816-a00d-fe4b64c3295a
relation.isAuthorOfPublicationf3994ffb-350b-4027-9c2e-e483de443965
relation.isAuthorOfPublication0e009212-6e81-435a-af49-be3ecd21f930
relation.isAuthorOfPublication.latestForDiscoveryf3994ffb-350b-4027-9c2e-e483de443965
upenn.schoolDepartmentCenterDepartmental Papers (Vet)
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