The hypothesis of this research project was that the degradation of CEPBA (a major transcription factor of rRNA in leukemic cells) would not impact the levels of PRPS6, MYC, and CTCF. This would then mean that the degradation of CEBPA is directly impacting rRNA production because CEBPA would not be able to facilitate binding of the Pol I to the rDNA. CEBPA was degraded in technical replicates for time points of 0, 0.5, 1, 1.5, 2, 3, and 4 hours. The 0 hour timepoint control would be the addition of DMSO at the same time as the 4 hour timepoint. Western blots were utilized to quantify the levels of the different target proteins. The results showed that there were minimal changes in the levels of PRPS6 and CTCF but MYC varied quite erratically amongst the different time points. Replicates will need to be done to confirm these results are accurate or determine if they were due to error.