Olfactory Inputs Modulate Respiration-Related Activity In The Prefrontal Cortex And Fear Behavior

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dc.contributor.advisorMinghong Ma
dc.contributor.authorMoberly, Andrew Henry
dc.contributor.authorMoberly, Andrew Henry
dc.date2023-05-17T21:56:41.000
dc.date.accessioned2023-05-22T17:32:51Z
dc.date.available2001-01-01T00:00:00Z
dc.date.copyright2019-04-02T20:18:00-07:00
dc.date.issued2018-01-01
dc.date.submitted2019-04-02T08:18:09-07:00
dc.description.abstractVoluntary control of respiration, especially via rhythmic nasal breathing, alleviates negative feelings such as fear and is used clinically to manage certain types of panic attacks. However, the neural substrates that link nasal breathing to fear circuits remains unknown. Here we show that during conditioned fear-induced freezing behavior, mice breathe at a steady rate (~4 Hz) which is strongly correlated with a predominant 4 Hz oscillation observed in the olfactory bulb and the prelimbic prefrontal cortex (plPFC), a structure critical for the expression of conditioned fear behaviors. We demonstrate anatomical and functional connectivity between the olfactory pathway and plPFC via circuit tracing and optogenetic approaches. Disrupting olfactory inputs significantly reduces the 4 Hz oscillation in the plPFC suggesting that respiration-related signals from the olfactory system play a role in entraining this fear-related signal. Surprisingly, we find that without olfactory inputs, freezing times are significantly prolonged. Collectively, our results indicate that olfactory inputs modulate rhythmic activity in fear circuits and suggest a neural pathway that may underlie the behavioral benefits of respiration-entrained olfactory signals.
dc.description.degreeDoctor of Philosophy (PhD)
dc.format.extent177 p.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/30155
dc.languageen
dc.legacy.articleid4947
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=4947&context=edissertations&unstamped=1
dc.provenanceReceived from ProQuest
dc.rightsAndrew Henry Moberly
dc.source.issue3161
dc.source.journalPublicly Accessible Penn Dissertations
dc.source.statuspublished
dc.subject.otherOlfaction
dc.subject.otherPrefrontal Cortex
dc.subject.otherRespiration
dc.subject.otherNeuroscience and Neurobiology
dc.titleOlfactory Inputs Modulate Respiration-Related Activity In The Prefrontal Cortex And Fear Behavior
dc.typeDissertation/Thesis
digcom.contributor.authorisAuthorOfPublication|email:mowglimacgruber@gmail.com|institution:University of Pennsylvania|Moberly, Andrew Henry
digcom.date.embargo2001-01-01T00:00:00-08:00
digcom.identifieredissertations/3161
digcom.identifier.contextkey14164843
digcom.identifier.submissionpathedissertations/3161
digcom.typedissertation
dspace.entity.typePublication
relation.isAuthorOfPublication073c4256-0841-4efb-b186-e08485ff32ba
relation.isAuthorOfPublication.latestForDiscovery073c4256-0841-4efb-b186-e08485ff32ba
upenn.graduate.groupNeuroscience
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