An Unbiased Test for the Bioequivalence Problem
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Statistics Papers
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two one-sided tests procedure
uniformly more powerful
pharmocokinetic parameters
Applied Statistics
Biostatistics
uniformly more powerful
pharmocokinetic parameters
Applied Statistics
Biostatistics
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Brown, Lawrence D
Hwang, J. T. Gene
Munk, Axel
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Abstract
It is shown that the standard two one-sided tests procedure for bioequivalence is a biased test. Better tests exist. In this paper, an unbiased α-level test and other tests which are uniformly more powerful than the two one-sided tests procedure are constructed. Its power can be noticeably larger than that of the α-level two one-sided tests procedure.
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1997
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The Annals of Statistics