The oxidation behavior of fully dense Ti2SC was studied thermogravimetrically in air in the 500–800°C temperature range. The oxidation product was a single-layer of rutile in all cases. At 800°C, the oxide layer was not protective and the oxidation kinetics were rapid. At 600 and 700°C, and up to ~50 h, the kinetics were parabolic before they became linear. It was only at 500°C that the weight gain reached a plateau after a 50 h initial parabolic regime. Mass spectrometry of the gases evolved during oxidation confirmed that both CO2 and SO2 are oxidation products. The overall oxidation reaction is thus Ti2SC + 4O2 → 2TiO2 + SO2 + CO2. On the basis of this and previous work, we conclude that oxidation occurs by the outward diffusion of titanium, sulfur, and carbon, the latter two either as atoms or in the form of CO2 and SO2 and, most probably, the inward diffusion of oxygen. Mesopores and microcracks were found in all rutile layers formed except those formed at 500°C. The presence of these defects is believed to have led to significantly higher oxidation rates as compared to other rutile-forming ternary carbides, such as Ti3SiC2.