Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

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dc.contributor.authorChen, Chih-Chiang
dc.contributor.authorWang, Lei
dc.contributor.authorPlikus, Maksim V.
dc.contributor.authorJiang, Ting Xin
dc.contributor.authorMurray, Phillip J.
dc.contributor.authorRamos, Raul
dc.contributor.authorGuerrero-Juarez, Christian F.
dc.contributor.authorHughes, Michael W.
dc.contributor.authorLee, Oscar K.
dc.contributor.authorShi, Songtao
dc.contributor.authorWidelitz, Randall B.
dc.contributor.authorLander, Arthur D.
dc.contributor.authorChuong, Cheng Ming
dc.date2023-05-18T00:26:05.000
dc.date.accessioned2023-05-22T13:13:10Z
dc.date.available2023-05-22T13:13:10Z
dc.date.issued2015-04-09
dc.date.submitted2021-03-03T06:24:12-08:00
dc.description.abstractCoordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair removal, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Removing hair at different densities leads to a regeneration of up to 5 times more neighboring, unplucked resting hairs, indicating activation of a collective decision-making process. Through data modeling, the range of the quorum signal was estimated to be on the order of 1 mm, greater than expected for a diffusible molecular cue. Molecular and genetic analysis uncovered a two-step mechanism, where release of CCL2 from injured hairs leads to recruitment of TNF-α secreting macrophages, which accumulate and signal to both plucked and unplucked follicles. By coupling immune response with regeneration, this mechanism allows skin to respond predictively to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/8884
dc.legacy.articleid1265
dc.legacy.fields10.1016/j.cell.2015.02.016
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1265&context=dental_papers&unstamped=1
dc.rights<p>© <2015>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license <a href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</a></p>
dc.source.beginpage277
dc.source.endpage290
dc.source.issue174
dc.source.issue2
dc.source.journalDepartmental Papers (Dental)
dc.source.journaltitleCell
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume161
dc.subject.otherDentistry
dc.titleOrgan-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations
dc.typeArticle
digcom.contributor.authorChen, Chih-Chiang
digcom.contributor.authorWang, Lei
digcom.contributor.authorPlikus, Maksim V.
digcom.contributor.authorJiang, Ting Xin
digcom.contributor.authorMurray, Phillip J.
digcom.contributor.authorRamos, Raul
digcom.contributor.authorGuerrero-Juarez, Christian F.
digcom.contributor.authorHughes, Michael W.
digcom.contributor.authorLee, Oscar K.
digcom.contributor.authorShi, Songtao
digcom.contributor.authorWidelitz, Randall B.
digcom.contributor.authorLander, Arthur D.
digcom.contributor.authorChuong, Cheng Ming
digcom.identifierdental_papers/174
digcom.identifier.contextkey21922201
digcom.identifier.submissionpathdental_papers/174
digcom.typearticle
dspace.entity.typePublication
upenn.schoolDepartmentCenterDepartmental Papers (Dental)
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