We report on a simple process to fabricate electrohydrodynamic spraying devices with superhydrophobic nozzles. These devices are useful, among other things, in mass spectrometry and printing technology. The superhydrophobic nozzle is created by roughening the surface of the polyfluorotetraethylene (PFTE) by argon and oxygen plasma treatment. We have developed a polymer-based electrospray device with a flat, superhydrophobic nozzle capable of maintaining a high contact angle and stable jetting.