Diabetes Mellitus Related Bone Metabolism and Periodontal Disease

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Departmental Papers (Dental)
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bone loss
diabetes mellitus
hyperglycemia
inflammation
osseous
osteoblast
osteoclast
periodontitis
Dentistry
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Wu, Ying-Ying
Xiao, E
Graves, Dana T
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Abstract

Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus. Alveolar bone loss is one of the main outcomes of periodontitis, and diabetes is among the primary risk factors for periodontal disease. In this review, we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects, focusing on alveolar bone loss. Bone remodelling begins with osteoclasts resorbing bone, followed by new bone formation by osteoblasts in the resorption lacunae. Therefore, we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.

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2015-01-01
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International Journal of Oral Science
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