Standardized Platform for Coregistration of Noncurrent Diffuse Optical and Magnetic Resonance Breast Images Obtained in Different Geometries

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Azar, Fred S
Lee, Kijoon
Khamene, Ali
Choe, Regine
Corlu, Alper
Konecky, Soren D
Sauer, Frank

We present a novel methodology for combining breast image data obtained at different times, in different geometries, and by different techniques. We combine data based on diffuse optical tomography (DOT) and magnetic resonance imaging (MRI). The software platform integrates advanced multimodal registration and segmentation algorithms, requires minimal user experience, and employs computationally efficient techniques. The resulting superposed 3-D tomographs facilitate tissue analyses based on structural and functional data derived from both modalities, and readily permit enhancement of DOT data reconstruction using MRI-derived a-priori structural information. We demonstrate the multimodal registration method using a simulated phantom, and we present initial patient studies that confirm that tumorous regions in a patient breast found by both imaging modalities exhibit significantly higher total hemoglobin concentration (THC) than surrounding normal tissues. The average THC in the tumorous regions is one to three standard deviations larger than the overall breast average THC for all patients.

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Suggested Citation: F.S. Azar et al. (2007)Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries. Journal of Biomedical Optics 12(5), 051902. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
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