Association Between β-Genus Human Papillomavirus and Cutaneous Squamous Cell Carcinoma in Immunocompetent Individuals—A Meta-analysis

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dc.contributor.authorChahoud, Jad
dc.contributor.authorSemaan, Adele
dc.contributor.authorChen, Yong
dc.date2023-05-17T17:27:06.000
dc.date.accessioned2023-05-22T19:05:14Z
dc.date.available2017-12-15T00:00:00Z
dc.date.issued2016-12-01
dc.date.submitted2017-06-30T09:24:04-07:00
dc.description.abstractIMPORTANCE Existing epidemiological evidence remains controversial regarding the association between β-genus human papillomavirus (β-HPV) and cutaneous squamous cell carcinoma (cSCC) in immunocompetent individuals. OBJECTIVE We aimed to clarify this association and evaluate type-specific β-HPV involvement. DATA SOURCES We performed a systematic literature search of MEDLINE and EMBASE for studies in humans through June 18, 2014, with no restriction on publication date or language. The following search terms were used: “human papillomavirus” and “cutaneous squamous cell carcinoma or skin squamous cell carcinoma or cSCC or nonmelanoma skin neoplasms.” STUDY SELECTION Articles were independently assessed by 2 reviewers. We only included case-control or cohort studies, in immunocompetent individuals, that calculated the odds ratio (OR) for cSCC associated with overall and type-specific β-HPV. DATA EXTRACTION AND SYNTHESIS We first assessed the heterogeneity among study-specific ORs using the Q statistic and I 2 statistic. Then, we used the random-effects model to obtain the overall OR and its 95% CI for all studies as well as for each type of HPV. We also tested and corrected for publication bias by 3 funnel plot–based methods. The quality of each study was assessed with the Newcastle Ottawa Scale. MAIN OUTCOMES AND MEASURES Pooled ORs and 95% CIs for overall β-HPV and HPV types 5, 8, 15, 17, 20, 24, 36, and 38 association with skin biopsy proven cSCC. RESULTS Seventy-nine articles were assessed for eligibility; 14 studies met inclusion criteria for the meta-analysis and included 3112 adult immunocompetent study participants with cSCC and 6020 controls. For all detection methods, the overall association between β-HPV and cSCC was significant with an adjusted pooled OR (95% CI) of 1.42 (1.18-1.72). As for the type-specific analysis, types 5, 8, 15, 17, 20, 24, 36, and 38 showed a significant association with adjusted pooled ORs (95% CIs) of 1.4 (1.18-1.66), 1.39 (1.16-1.66), 1.25 (1.04-1.50), 1.34 (1.19-1.52), 1.38 (1.21-1.59), 1.26 (1.09-1.44), 1.23 (1.01-1.50), and 1.37 (1.13-1.67) respectively. Our subgroup analysis in studies using only serology for HPV detection showed a significant association between overall β-HPV and HPV subtypes 5, 8, 17, 20, 24, and 38 with an increased risk of cSCC development. CONCLUSIONS AND RELEVANCE This study serves as added evidence supporting β-HPV as a risk factor for cSCC in healthy individuals. The subgroup analysis highlights this significant association for HPV 5, 8, 17, 20, and 38, which may help to direct future prevention efforts
dc.description.commentsChahoud J, Semaan A, Chen Y, Cao M, Rieber AG, Rady P, Tyring SK. Association Between β-Genus Human Papillomavirus and Cutaneous Squamous Cell Carcinoma in Immunocompetent Individuals—A Meta-analysis. JAMA Dermatol. 2016;152(12):1354-1364. doi: dx.doi.org/10.1001/jamadermatol.2015.4530
dc.formatflash_audio
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/33172
dc.legacy.articleid1007
dc.legacy.fieldstrue
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1007&context=epidemiology&unstamped=1
dc.source.issue8
dc.source.journalDepartment of Biostatistics, Epidemiology and Informatics
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.subject.otherPapillomavirus
dc.subject.otherCarcinoma
dc.subject.otherImmunocompetent
dc.subject.otherEpidemiology
dc.subject.otherMedicine and Health Sciences
dc.subject.otherPublic Health
dc.titleAssociation Between β-Genus Human Papillomavirus and Cutaneous Squamous Cell Carcinoma in Immunocompetent Individuals—A Meta-analysis
dc.typeArticle
digcom.date.embargo2017-12-15T00:00:00-08:00
digcom.identifierepidemiology/8
digcom.identifier.contextkey10381577
digcom.identifier.submissionpathepidemiology/8
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublication85e7d79d-9fb3-4cde-85c8-0d26c575d87e
relation.isAuthorOfPublication85e7d79d-9fb3-4cde-85c8-0d26c575d87e
relation.isAuthorOfPublication.latestForDiscovery85e7d79d-9fb3-4cde-85c8-0d26c575d87e
upenn.schoolDepartmentCenterDepartment of Biostatistics, Epidemiology and Informatics
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