For latest version: please go to https://academicentrepreneurship.pubpub.org/pub/47slx657/release/3 The process of disruptive innovation is a driving force in making healthcare more affordable and effective. Building resilience through diversification of financial resources, networking, and focusing time/effort can help an academic entrepreneur tolerate setbacks and minimize risks. The sleep medicine case study highlights how fast a disruptive innovation can impact organizations on a micro and macro level.