Composers through the centuries have tried to depict Dante’s Commedia in music, using Dante’s verses, characters, and design for Hell, Purgatory, and Heaven, and their compositions. This paper looks at some of the trends in musical adaptations of the Commedia and also some of the “greatest hits”—in the author’s opinion. Works by James Norton, Patric Standford, Jacob ter Veldhuis, David Denniston, Franz Liszt, Donald Martino, Tod Machover, Anita Saij, Allik and Mulder, and Theodore Wiprud are discussed.