Dental and Orofacial Mesenchymal Stem Cells in Craniofacial Regeneration: a Prosthodontist’s Point of View

Simple item page
dc.contributor.authorAnsari, Sahar
dc.contributor.authorSeagroves, Jackson T.
dc.contributor.authorChen, Chider
dc.contributor.authorShah, Kumar
dc.contributor.authorAghaloo, Tara
dc.contributor.authorWu, Benjamin M.
dc.contributor.authorBencharit, Sompop
dc.contributor.authorMoshaverinia, Alireza
dc.date2023-05-18T00:37:48.000
dc.date.accessioned2023-05-22T13:12:32Z
dc.date.available2023-05-22T13:12:32Z
dc.date.issued2017-10-01
dc.date.submitted2021-05-04T07:15:47-07:00
dc.description.abstractOf the available regenerative treatment options, craniofacial tissue regeneration using mesenchymal stem cells (MSCs) shows promise. The ability of stem cells to produce multiple specialized cell types along with their extensive distribution in many adult tissues have made them an attractive target for applications in tissue engineering. MSCs reside in a wide spectrum of postnatal tissue types and have been successfully isolated from orofacial tissues. These dental-or orofacial-derived MSCs possess self-renewal and multilineage differentiation capacities. The craniofacial system is composed of complex hard and soft tissues derived from sophisticated processes starting with embryonic development. Because of the complexity of the craniofacial tissues, the application of stem cells presents challenges in terms of the size, shape, and form of the engineered structures, the specialized final developed cells, and the modulation of timely blood supply while limiting inflammatory and immunological responses. The cell delivery vehicle has an important role in the in vivo performance of stem cells and could dictate the success of the regenerative therapy. Among the available hydrogel biomaterials for cell encapsulation, alginate-based hydrogels have shown promising results in biomedical applications. Alginate scaffolds encapsulating MSCs can provide a suitable microenvironment for cell viability and differentiation for tissue regeneration applications. This review aims to summarize current applications of dental-derived stem cell therapy and highlight the use of alginate-based hydrogels for applications in craniofacial tissue engineering.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/8825
dc.legacy.articleid1316
dc.legacy.fields10.1016/j.prosdent.2016.11.021
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1316&context=dental_papers&unstamped=1
dc.rights© <2017>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.beginpage455
dc.source.endpage461
dc.source.issue120
dc.source.issue4
dc.source.journalDepartmental Papers (Dental)
dc.source.journaltitleJournal of Prosthetic Dentistry
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume118
dc.subject.otherDentistry
dc.titleDental and Orofacial Mesenchymal Stem Cells in Craniofacial Regeneration: a Prosthodontist’s Point of View
dc.typeArticle
digcom.contributor.authorAnsari, Sahar
digcom.contributor.authorSeagroves, Jackson T.
digcom.contributor.authorChen, Chider
digcom.contributor.authorShah, Kumar
digcom.contributor.authorAghaloo, Tara
digcom.contributor.authorWu, Benjamin M.
digcom.contributor.authorBencharit, Sompop
digcom.contributor.authorMoshaverinia, Alireza
digcom.identifierdental_papers/120
digcom.identifier.contextkey22779506
digcom.identifier.submissionpathdental_papers/120
digcom.typearticle
dspace.entity.typePublication
upenn.schoolDepartmentCenterDepartmental Papers (Dental)
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
blank.pdf
Size:
877.83 KB
Format:
Adobe Portable Document Format
Download
Collection
Articles