Leveraging a Rapid, Round-the-Clock HIV Testing System to Screen for Acute HIV Infection in a Large Urban Public Medical Center

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dc.contributor.authorChristopoulos, Katerina A
dc.contributor.authorZetola, Nicola M
dc.contributor.authorKlausner, Jeffrey D
dc.contributor.authorHaller, Barbara
dc.contributor.authorLouie, Brian
dc.contributor.authorHare, Bradley
dc.contributor.authorPandori, Mark
dc.contributor.authorNassos, Patricia
dc.contributor.authorRoemer, Marguerite
dc.contributor.authorPilcher, Christopher D
dc.date2023-05-17T09:51:03.000
dc.date.accessioned2023-05-22T12:38:20Z
dc.date.available2023-05-22T12:38:20Z
dc.date.issued2013-02-01
dc.date.submitted2014-11-04T08:39:31-08:00
dc.description.abstractMethods The hospital laboratory performed round-the-clock rapid HIV antibody testing on venipuncture specimens from patients undergoing HIV testing in hospital and community clinics, inpatient settings, and the emergency department. For patients with negative results, a public health laboratory conducted pooled HIV RNA testing for acute HIV infection. The laboratories communicated positive results from the hospital campus to a linkage team. Linkage was defined as one outpatient HIV-related visit. Results Among 7,927 patients, 8,550 rapid tests resulted in 137 cases of HIV infection (1.7%, 95% CI 1.5%–2.0%), of whom 46 were new HIV diagnoses (0.58%, 95% CI 0.43%–0.77%). Pooled HIV RNA testing of 6,704 specimens (78.4%) resulted in 3 cases of acute HIV infection (0.05%, 95% CI 0.01%–0.14) and increased HIV case detection by 3.5%. Half of new HIV diagnoses and 2/3 of acute infections were detected in the emergency department and urgent care clinic. Rapid test sensitivity was 98.9% (95% CI 93.8%– 99.8%); specificity was 99.9% (95% CI 99.7%–99.9%). Over 95% of newly diagnosed and out-of-care HIV-infected patients were linked to care. Conclusions Patients undergoing HIV testing in emergency departments and urgent care clinics may benefit from being simultaneously screened for acute HIV infection.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/5590
dc.legacy.articleid1042
dc.legacy.fields10.1097/QAI.0b013e31827a0b0d
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1042&context=botswana_schol&unstamped=1
dc.rightsThis is a non-final version of an article published in final form at J Acquir Immune Defic Syndr. Feb 1, 2013; 62(2): e30–e38. doi: http://dx.doi.org/10.1097%2FQAI.0b013e31827a0b0d
dc.source.beginpagee30
dc.source.endpagee38
dc.source.issue22
dc.source.issue2
dc.source.journalBotswana-UPenn Scholarly Publications
dc.source.journaltitleJournal of Acquired Immune Deficiency Syndromes
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume62
dc.subject.otherHIV serodiagnosis; HIV rapid tests; acute HIV infection; HIV testing in medical settings
dc.subject.otherDiseases
dc.subject.otherImmune System Diseases
dc.subject.otherMedicine and Health Sciences
dc.titleLeveraging a Rapid, Round-the-Clock HIV Testing System to Screen for Acute HIV Infection in a Large Urban Public Medical Center
dc.typeArticle
digcom.contributor.authorChristopoulos, Katerina A
digcom.contributor.authorisAuthorOfPublication|email:nzetola@gmail.com|institution:University of Pennsylvania|Zetola, Nicola M
digcom.contributor.authorKlausner, Jeffrey D
digcom.contributor.authorHaller, Barbara
digcom.contributor.authorLouie, Brian
digcom.contributor.authorHare, Bradley
digcom.contributor.authorPandori, Mark
digcom.contributor.authorNassos, Patricia
digcom.contributor.authorRoemer, Marguerite
digcom.contributor.authorPilcher, Christopher D
digcom.identifierbotswana_schol/22
digcom.identifier.contextkey6323125
digcom.identifier.submissionpathbotswana_schol/22
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublication9de7f001-3892-49e8-b664-f7ed4c6fde51
relation.isAuthorOfPublication.latestForDiscovery9de7f001-3892-49e8-b664-f7ed4c6fde51
upenn.schoolDepartmentCenterBotswana-UPenn Scholarly Publications
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