Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress

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dc.contributor.authorPonugoti, Bhaskar
dc.contributor.authorGraves, Dana T
dc.contributor.authorGraves, Dana T
dc.date2023-05-17T11:18:58.000
dc.date.accessioned2023-05-22T13:12:39Z
dc.date.available2023-05-22T13:12:39Z
dc.date.issued2012-01-01
dc.date.submitted2015-03-31T12:15:47-07:00
dc.description.abstractDiabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications. The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO6 play important roles in the regulation of many cellular and biological processes and are critical regulators of cellular oxidative stress response pathways. FOXO1 transcription factors can affect a number of different tissues including liver, retina, bone, and cell types ranging from hepatocytes to microvascular endothelial cells and pericytes to osteoblasts. They are induced by oxidative stress and contribute to ROS-induced cell damage and apoptosis. In this paper, we discuss the role of FOXO transcription factors in mediating oxidative stress-induced cellular response.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/8835
dc.legacy.articleid1012
dc.legacy.fields10.1155/2012/939751
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1012&context=dental_papers&unstamped=1
dc.rights<p>Copyright © 2012 Bhaskar Ponugoti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
dc.source.beginpageArticle ID 939751
dc.source.issue13
dc.source.journalDepartmental Papers (Dental)
dc.source.journaltitleExperimental Diabetes Research
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume2012
dc.subject.otherDiabetes Mellitus
dc.subject.otherForkhead Transcription Factors
dc.subject.otherHumans
dc.subject.otherLiver
dc.subject.otherOxidative Stress
dc.subject.otherReactive Oxygen Species
dc.subject.otherEndocrinology, Diabetes, and Metabolism
dc.subject.otherMedical Cell Biology
dc.titleRole of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress
dc.typeArticle
digcom.contributor.authorPonugoti, Bhaskar
digcom.contributor.authorDong, Guangyu
digcom.contributor.authorisAuthorOfPublication|email:dtgraves@dental.upenn.edu|institution:University of Pennsylvania|Graves, Dana T
digcom.identifierdental_papers/13
digcom.identifier.contextkey6925507
digcom.identifier.submissionpathdental_papers/13
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublication75423858-1a3e-4959-a23f-4a8843f0d286
relation.isAuthorOfPublication75423858-1a3e-4959-a23f-4a8843f0d286
relation.isAuthorOfPublication.latestForDiscovery75423858-1a3e-4959-a23f-4a8843f0d286
upenn.schoolDepartmentCenterDepartmental Papers (Dental)
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