Acute Vascular Occlusion in Horses: Effects on Skeletal Muscle Size and Blood Flow

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dc.contributor.authorAbe, Takashi
dc.contributor.authorKearns, Charles F
dc.contributor.authorManso Filho, Hélio C
dc.contributor.authorSleeper, Margaret M
dc.contributor.authorSleeper, Margaret M
dc.contributor.authorMcKeever, Kenneth H
dc.date2023-05-17T07:55:52.000
dc.date.accessioned2023-05-23T04:44:57Z
dc.date.available2023-05-23T04:44:57Z
dc.date.issued2004-11-01
dc.date.submitted2013-08-05T11:22:15-07:00
dc.description.abstractThe purpose of this study was to demonstrate whether acute vascular occlusion was safe and if it would result in changes to limb muscle size in horses. Six healthy, unfit Standardbred mares were used. Horses (standing at rest) wore an occlusion cuff at the most proximal position of the left forelimb. The right forelimb was used as control. An occlusion pressure of 200 mmHg was set for 5 min followed by a 2 min recovery. Three sets of occlusions were given to each horse. Muscle thickness was measured using B-mode ultrasound. The circumference of the forelimb and first phalanx was measured using a flexible tape measure. Pulsed-wave Doppler was performed on the radialis artery with a 5–10 MHz mechanical transducer at baseline and at each occlusion. Peak flow velocity (PFV) and the flow velocity integral (FVI) were measured each time. Mid-forelimb, but not first phalanx, girth was increased (P < 0.05) in the occluded but not in the control leg following occlusion. Extensor and flexor muscle thickness was increased (P < 0.05) in the occluded but not in the control leg. There were no changes (P > 0.05) in PFV or FVI at any measurement time point. Acute vascular occlusion may be a suitable and safe model for studying muscle hypertrophy in horses.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/48923
dc.legacy.articleid1015
dc.legacy.fieldstrue
dc.legacy.fields10.1079/ECP200429
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1015&amp;context=vet_papers&amp;unstamped=1
dc.rights<p>Copyright © Cambridge University Press 2004, this journal can be found online at <a href="http://journals.cambridge.org/action/displayJournal?jid=ECP">http://journals.cambridge.org/action/displayJournal?jid=ECP</a></p>
dc.source.beginpage239
dc.source.endpage243
dc.source.issue16
dc.source.issue4
dc.source.journalDepartmental Papers (Vet)
dc.source.journaltitleEquine and Comparative Exercise Physiology
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume1
dc.subject.othermuscle thickness
dc.subject.otherplasma lactate
dc.subject.otherpacked cell volume
dc.subject.otherkaatsu-training
dc.subject.otherLarge or Food Animal and Equine Medicine
dc.subject.otherMedicine and Health Sciences
dc.subject.otherRehabilitation and Therapy
dc.subject.otherVeterinary Medicine
dc.titleAcute Vascular Occlusion in Horses: Effects on Skeletal Muscle Size and Blood Flow
dc.typeArticle
digcom.contributor.authorAbe, Takashi
digcom.contributor.authorKearns, Charles F
digcom.contributor.authorManso Filho, Hélio C
digcom.contributor.authorSato, Yoshiaki
digcom.contributor.authorisAuthorOfPublication|email:sleeper@vet.upenn.edu|institution:University of Pennsylvania|Sleeper, Margaret M
digcom.contributor.authorMcKeever, Kenneth H
digcom.identifiervet_papers/16
digcom.identifier.contextkey4390732
digcom.identifier.submissionpathvet_papers/16
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublicationba1391f5-a1f2-456f-ad2c-db0d1076abda
relation.isAuthorOfPublicationba1391f5-a1f2-456f-ad2c-db0d1076abda
relation.isAuthorOfPublication.latestForDiscoveryba1391f5-a1f2-456f-ad2c-db0d1076abda
upenn.schoolDepartmentCenterDepartmental Papers (Vet)
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