Colloidal Particle Motion as a Diagnostic of DNA Conformational Transitions
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Tethered motion
Hidden Markov
DNA conformation
DNA looping
Single-particle tracking
Physical Sciences and Mathematics
Physics
Hidden Markov
DNA conformation
DNA looping
Single-particle tracking
Physical Sciences and Mathematics
Physics
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Abstract
Tethered particle motion is an experimental technique to monitor conformational changes in single molecules of DNA in real time, by observing the position fluctuations of a micrometer-size particle attached to the DNA. This article reviews some recent work on theoretical problems inherent in the interpretation of TPM experiments, both in equilibrium and dynamical aspects.
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2007-12-01
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Current Opinion in Colloid & Interface Science