Consistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA

Simple item page
dc.contributor.authorStefanovski, Darko
dc.contributor.authorStefanovski, Darko
dc.contributor.authorRichey, Joyce M
dc.contributor.authorWoolcott, Orison
dc.contributor.authorLottati, Maya
dc.contributor.authorZheng, Dan
dc.contributor.authorHarrison, Lisa N
dc.contributor.authorIonut, Viorica
dc.contributor.authorKim, Stella P
dc.contributor.authorBergman, Richard N
dc.date2023-05-17T11:07:02.000
dc.date.accessioned2023-05-23T04:44:43Z
dc.date.available2023-05-23T04:44:43Z
dc.date.issued2011-03-30
dc.date.submitted2015-01-23T11:06:04-08:00
dc.description.abstractObjective Insulin resistance induces hyperinsulinemic compensation, which in turn maintains almost a constant disposition index. However, the signal that gives rise to the hyperinsulinemic compensation for insulin resistance remains unknown. Methods In a dog model of obesity we examined the possibility that potential early-week changes in plasma FFA, glucose, or both could be part of a cascade of signals that lead to compensatory hyperinsulinemia induced by insulin resistance. Results Hypercaloric high fat feeding in dogs resulted in modest weight gain, and an increase in adipose tissue with no change in the non-adipose tissue size. To compensate for the drop in insulin sensitivity, there was a significant rise in plasma insulin, which can be attributed in part to a decrease in the metabolic clearance rate of insulin and increased insulin secretion. In this study we observed complete compensation for high fat diet induced insulin resistance as measured by the disposition index. The compensatory hyperinsulinemia was coupled with significant changes in plasma FFAs and no change in plasma glucose. Conclusions We postulate that early in the development of diet induced insulin resistance, a change in plasma FFAs may directly, through signaling at the level of β-cell, or indirectly, by decreasing hepatic insulin clearance, result in the observed hyperinsulinemic compensation.
dc.description.comments<p>At the time of publication, author Darko Stefanovski was affiliated with the University of Southern California. Currently, he is a faculty member at the University of Pennsylvania's School of Veterinary Medicine.</p>
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/48903
dc.legacy.articleid1096
dc.legacy.fields10.1371/journal.pone.0018134
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1096&amp;context=vet_papers&amp;unstamped=1
dc.rights<p>© 2011 Stefanovski, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p>
dc.source.beginpagee18134
dc.source.issue141
dc.source.issue3
dc.source.journalDepartmental Papers (Vet)
dc.source.journaltitlePLoS ONE
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume6
dc.subject.otherMedicine and Health Sciences
dc.titleConsistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA
dc.typeArticle
digcom.contributor.authorisAuthorOfPublication|email:sdarko@vet.upenn.edu|institution:University of Pennsylvania|Stefanovski, Darko
digcom.contributor.authorRichey, Joyce M
digcom.contributor.authorWoolcott, Orison
digcom.contributor.authorLottati, Maya
digcom.contributor.authorZheng, Dan
digcom.contributor.authorHarrison, Lisa N
digcom.contributor.authorIonut, Viorica
digcom.contributor.authorKim, Stella P
digcom.contributor.authorBergman, Richard N
digcom.identifiervet_papers/141
digcom.identifier.contextkey6558955
digcom.identifier.submissionpathvet_papers/141
digcom.typearticle
dspace.entity.typePublication
relation.isAuthorOfPublication6f18de03-4ea6-4da8-b38a-5cb00310137e
relation.isAuthorOfPublication.latestForDiscovery6f18de03-4ea6-4da8-b38a-5cb00310137e
upenn.schoolDepartmentCenterDepartmental Papers (Vet)
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
journal.pone.0018134.pdf
Size:
305.31 KB
Format:
Adobe Portable Document Format
Download
Collection
Articles