Self-Assembled Charged Hydrogels Control the Alignment of Filamentous Actin

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dc.contributor.authorPark, Jung Hyun Hyun
dc.contributor.authorGoldman, Yale E.
dc.contributor.authorComposto, Russell J
dc.contributor.authorSun, Yujie
dc.date2023-05-17T05:32:20.000
dc.date.accessioned2023-05-23T00:04:00Z
dc.date.available2023-05-23T00:04:00Z
dc.date.issued2009-01-01
dc.date.submitted2010-11-09T08:40:30-08:00
dc.description.abstractWe demonstrate a novel route to control attachment of filamentous actin (F-actin) on hydrogel films. By incorporating an amine-terminated silane, the hydrogel surface charge and surface topography are varied. With increasing silane content, F-actin reorients from perpendicular to parallel to the hydrogel surface, ceases to wobble, and forms mainly elongated or cyclic structures. F-Actin coverage reaches a maximum at 2.5 vol% silane and declines at higher silane content. This biphasic behavior is explained by the simultaneous increase in surface charge and the self-assembly of a micron scale pattern of positively charged islands. Our approach provides guidelines for constructing nanoscale tracks to guide motor proteins underlying nano-engineered devices such as molecular shuttles.
dc.description.commentsSuggested Citation: Park, J.H., Y. Sun, Y.E. Goldman and R.J. Composto. (2010). "Self-assembled charged hydrogels control the alignment of filamentous actin." Soft Matter. Vol. 6:5. pp. 915-921 © 2010 Royal Society of Chemistry http://dx.doi.org/10.1039/B918304C
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/41031
dc.legacy.articleid1202
dc.legacy.fieldstrue
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1202&context=mse_papers&unstamped=1
dc.source.issue184
dc.source.journalDepartmental Papers (MSE)
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.subject.otherEngineering
dc.subject.otherMaterials Science and Engineering
dc.titleSelf-Assembled Charged Hydrogels Control the Alignment of Filamentous Actin
dc.typeArticle
digcom.contributor.authorisAuthorOfPublication|email:jnpark@seas.upenn.edu|institution:University of Pennsylvania|Park, Jung Hyun Hyun
digcom.contributor.authorSun, Yujie
digcom.contributor.authorisAuthorOfPublication|email:goldmany@mail.med.upenn.edu|institution:University of Pennsylvania|Goldman, Yale E.
digcom.contributor.authorisAuthorOfPublication|email:composto@lrsm.upenn.edu|institution:University of Pennsylvania|Composto, Russell J
digcom.identifiermse_papers/184
digcom.identifier.contextkey1635621
digcom.identifier.submissionpathmse_papers/184
digcom.typearticle
dspace.entity.typePublication
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relation.isAuthorOfPublicationcd032144-5fc1-413e-82ed-789605da3071
relation.isAuthorOfPublication.latestForDiscoveryeee4e1d0-cfa2-4173-b202-973ad2b76ceb
upenn.schoolDepartmentCenterDepartmental Papers (MSE)
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