Departmental Papers (EES)

Document Type

Journal Article

Date of this Version

2014

Publication Source

Environmental Chemistry

Volume

11

Start Page

431

Last Page

444

DOI

10.1071/EN13218

Abstract

Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.

Copyright/Permission Statement

Creative Commons Attribution-NonCommercial-NoDerivs 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/deed.en_US)

Comments

At the time of publication, author Reto Gieré was affiliated with the Institute of Earth and Environmental Sciences Geochemistry, University of Freiburg. Currently, he is a faculty member in the Earth & Environmental Department at the University of Pennsylvania.

Keywords

biodegradation, HeLa cells, Hep-G2 cells, irradiation, predicted environmental concentrations (PECs), UV, Vibrio fischeri

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Date Posted: 25 April 2017

This document has been peer reviewed.