BDNF administration after traumatic brain injury in the rat

Gregory Robert Blaha, University of Pennsylvania


Brain-derived neurotrophic factor (BDNF) has been shown to have numerous cellular effects and to be protective in a wide variety of experimental insults, including excitotoxicity, axotomy and ischemia. The present study examined whether BDNF could be a potential treatment for traumatic brain injury (TBI) using the lateral fluid-percussion (LFP) model in the rat. BDNF was infused into either the hippocampus or the cortex (at one of two different doses) starting 3–4 hours after injury and continuing for 2 weeks. Animals were evaluated by means of the following outcome measures: neurological motor ability at 2 days, 1 week, and 2 weeks; learning and memory in a water maze at 2 weeks; neuronal loss in the CA3, dentate hilus, and medial geniculate nucleus at 2 weeks; and size of cortical lesion at two weeks. A significant effect of injury was seen in all of the above measures, however BDNF treatment was not able to significantly improve any of these deficits when compared to vehicle-infusion.

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Recommended Citation

Blaha, Gregory Robert, "BDNF administration after traumatic brain injury in the rat" (2000). Dissertations available from ProQuest. AAI9965445.