Development of a laser Doppler flowmeter with eye movement cancellation and its application to human optic nerve head
Previous investigations of blood flow in the optic nerve have been limited by the lack of an effective technique that can be applied in humans. While Laser Doppler velocimetry and flowmetry provide non-invasive, direct, quantitative means for measuring ocular blood flow, eye movement artifacts are a continuing difficulty when performing these measurements in humans. A laser Doppler flowmeter with eye-movement cancellation was developed and used to investigate the regulation of blood flow in the human optic nerve head in response to a stimulus of diffuse luminance flicker. The ability of the eye-tracking Laser Doppler velocimeter to continuously record retinal arterial velocity in the presence of smooth pursuit motion is demonstrated. Furthermore the contribution and limitations of stabilization to the measurement of optic nerve head blood flow during steady fixation is also demonstrated. Finally, it is shown that a stimulus of diffuse luminance flicker induces an increase in optic nerve head blood flow.
Mendel, Mark Joseph, "Development of a laser Doppler flowmeter with eye movement cancellation and its application to human optic nerve head" (1995). Dissertations available from ProQuest. AAI9532245.