Coarse-grained cytoskeleton and filament simulations and mimicry with polymer worm micelles

Paul M Dalhaimer, University of Pennsylvania

Abstract

Mimicry of cellular components is a logical starting point for creating sophisticated materials and also aids in the understanding of the model biological machinery. This thesis explores the mimicry of cytoskeletal biopolymers with giant worm micelles. In particular, the bending rigidity of the worm micelles can be chemically tuned to match the rigidity of intermediate filaments to microtubules. It is also shown here that the exterior of the worm micelles can be chemically modified with small ligands and peptides that bind specifically to cell membrane receptors. Preceding the design and work on these worm micelles, statistical mechanical approaches were used to elaborate the general phase behavior and surface interaction properties of cytoskeletal biopolymers. In the end, the worm micelles were incorporated back into a biological environment as drug delivery vehicles.

Subject Area

Chemical engineering

Recommended Citation

Dalhaimer, Paul M, "Coarse-grained cytoskeleton and filament simulations and mimicry with polymer worm micelles" (2003). Dissertations available from ProQuest. AAI3109169.
https://repository.upenn.edu/dissertations/AAI3109169

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