This series contains theses from the University of Pennsylvania School of Dental Medicine. For more information about University of Pennsylvania dissertation/theses requirements and guidelines, please consult the dissertation manual.

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Theses/Dissertations from 2022

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18F-FDG-PET/CT in Radiation Therapy-Induced Cerebellar Inflammation, Mohammad Abu Kar, Abass Alavi, Johnathan M. Korostoff, Joseph P. Fiorellini, and Yu-Cheng Chang

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Predictability of the Implant Procedure on the Edentulous Ridge, Abdulaziz Alhossan, Joseph P. Fiorellini, Yu-Cheng Chang, Yu (Taylor) Wang, and Hector Sarmiento

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A New Clinical Use Of Catalytic Iron Oxide Nanoparticles For Endodontic Treatment, Alaa Babeer

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The Effect of Different Surface Treatments on The Bond Strength of Zirconia, Kushaldeep FNU

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Preliminary Analysis of Transcriptomic Variations in Esrp1/Sox2 Double Transgenic Mouse Embryo Facial Prominences in Search of Esrp1 Targets Responsible for Cleft Lip and/or Palate Pathogenesis, Grace Lee

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The Effect Of Different Cleaning Agents On The Bond Strength Of Contaminated Zirconia, Leen Musharbash

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In Vitro Comparative Study Between Full-Arch Conventional Implant Impressions and Full-Arch Digital Implant Impressions with Snap-on Scan Bodies, Thomas H. Yoo

Theses/Dissertations from 2021

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Periapical Healing following Endodontic Microsurgery with Collagen Based Bone Filling Material: A Randomized Controlled Clinical Trial, Amenah Albagle

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A Qualitative Systematic Review of the Association of Sleep Disturbances with Burning Mouth Syndrome: An Overlooked Relationship, Fatmah J. Alhendi DDS; Patricia Corby DDS, MS; Eugene KO DDS; Laurel Graham MLS; Sunday Akintoye BDS, DDS, MS; and Takako Tanaka DDS, FDS, RCSEd

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Marginal Adaptation of CAD/CAM Hybrid Ceramic Crowns Made on Preparations With and Without Surface Finishing, Faisal Al-Hussainy, Julian Conejo, Eva Anadioti, Francis K. Mante, and Markus B. Blatz

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Quality of Life in Patients with Oral Potentially Malignant Disorders: Oral Lichen Planus and Oral Epithelial Dysplasia, Rawan Ahmad Ashshi, Dani Stanbouly, and Pietro Maisano

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Effect of Adjunct Antibiotics in the Treatment of Peri-Implant Disease: A Systematic Review and Meta-Analysis, Ya-Wei Chen

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Diabetes Impairs Fracture Healing Through Foxo1-Mediated Downregulation of IFT80 and Disruption of Ciliogenesis, Zahra Chinipardaz

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Factors associated with survival of teeth following initial endodontic therapy, Minyoung Choi

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MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction, Chalatip Chompunud Na Ayudhya

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INCIDENCE OF DENTAL IMPLANT FAILURE IN ACADEMIC SETTING - A CLINICAL RETROSPECTIVE STUDY PART ONE: PATIENT LEVEL, Reza Hakim Shoushtari

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INCIDENCE OF DENTAL IMPLANT FAILURE IN AN ACADEMIC SETTING - A CLINICAL RETROSPECTIVE STUDY PART TWO: IMPLANT LEVEL ANALYSIS, Omar A A Mohammad

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Transcriptome and Methylome of Human Gingival Tissues in Periodontal Health and Disease, Shaked Navat Pelli DMD

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Metabolic Reprogramming Steers Stem Cell Evolution, Juyoung Park

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Bond Strength of Different Self-Adhesive Resin Cements to Zirconia, Nupur Patel, Eva Anadioti, Julial Conejo, Fusun Ozer, Francis Mante, and Markus Blatz

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EVALUATION OF LONG-TERM EFFICACY OF FORCED ERUPTED TEETH FOR RESTORATIVE PURPOSES – A CLINICAL RETROSPECTIVE STUDY, Mohammad Taqi Qali

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The Effect of Different Polishing Protocols on Surface Topography and Roughness of Provisional and Semi-Permanent Prosthodontic Materials, Lucie Zi Xuan Yin

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Single Cell Transcriptomics Identifies Mesenchymal Stem Cell Lineage Trajectories During Maxillary Expansion, Xuefeng Zhao

Theses/Dissertations from 2020

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MRGPRX2 Signaling in Mast Cells and Mastocytosis (Urticaria Pigmentosa), Abdulaziz Alblaihess

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The Interplay of Hypoxia and Autophagy in Epithelial-Derived Ameloblastoma Cell Survival: A Pilot Study, Anwar A A Y AlMuzaini

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Characterization of Malignant Transforming Oral Lichen Planus, A 13-Year Retrospective Clinicopathological Study in A Tertiary Center and Review of the Literature, Mohammed Bindakhil

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THE ROLE OF LGR5+ EPITHELIAL STEM-LIKE CELLS IN 3D-ORGANOID MODELING AND PATHOGENESIS OF AMELOBLASTOMA, Ting-Han Chang

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Comparison of Bone- and Tooth-Anchored, Bone-Anchored, and Surgically Assisted Bone-Anchored Rapid Palatal Expansion: a Pilot Retrospective CBCT Study, Douglas Kim

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The Dual Roles of NF-kB Activation in Prx1+ Mesenchymal Cells in Health and Disease, Kang I. Ko

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18F-FDG-PET/CT in Radiation Therapy-Induced Parotid Gland Inflammation, Alaa Mouminah

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Adjunctive Therapy of Periodontal Disease with Minocycline Microspheres in Dental School Settings: A Retrospective Chart Review., Artem Shurduk

Theses/Dissertations from 2019

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Dental Implant Failure Rate and Marginal Bone Loss in Smokers Compared to Non-Smokers: A Systematic Review and Meta-Analysis, Mohammad S. Akel

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The Mechanism KSHV Plays in Mesenchymal to Endothelial Transition in Kaposi Sarcoma, Sausan Alfaris

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Gingival MSCs Improve Bone Phenotype in Ovariectomy-Induced Osteoporosis via Programmed Cell Death Pathway, Sultan Alghaithi

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The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function, Ibrahim S. Alkanfari

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The Role 18F-FDG and 18F-NaF PET/CT in Assessment of Temporomandibular Joint Metabolic Activity in Rheumatoid Arthritis, Abdulrahman A. Aseri

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Following Surgically Assisted Rapid Palatal Expansion, Do Tooth-Borne or Bone-Borne Appliances Provide More Skeletal Expansion and Dental Expansion?, Adrien Hamedi-Sangsari

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Dextran-coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Biofilm Disruption and Caries Prevention, Yuan Liu

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The Change of Alveolar Bone Thickness on Mandibular Central Incisors of Skeletal Class II Patients After Orthodontic Treatment Using Cone-Beam Computed Tomography., Kensuke Matsumoto, Scott Sherrill-Mix, Normand Boucher, and Nipul Tanna

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Gingival Taste Bud Papillae Associated with Retromolar Salivary Gland, Quan Nguyen, Marco Tizzano, Bekir Karabucak, and Grace Beck Coburn

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New Periodontal Pathogens and their Biogeography in ex Vivo Biofilms, Fany B. Ocampo

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The Role of IL-6 in Osteogenic and Neurogenic Differentiation Potentials of Dental Pulp Stem Cells (DPSCs), YongTae Park, Xiaoxing Kou, and Songtao Shi

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Outcome of Immediate Versus Delayed Loading of Full Arch Implant-Supported Fixed Prosthesis: A Systematic Review and Meta-Analysis, Chanathip Srisuthep

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Determining the Role of TLR2 and TLR3 Synergy from Myd88-Dependent Inflammatory Responses, Hellen Teixeira

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In-Vitro Comparative Evaluation of the Physical Properties of Three Dimensional-Printed and Milled High Performance Ceramics, laura torrecillas-martinez

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Craniofacial growth of untreated children: A longitudinal CBCT study, Leah S. Yi

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The Homeostatic Factor Del-1 Promotes Periodontal Bone Regeneration During Resolution of Periodontitis, DA-YO YUH

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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand, Bassam N. Zidane

Theses/Dissertations from 2018

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Effect of Dental Scaling and Root Planing on Serum Inflammatory Markers in Patients with Coronary Heart Disease: A Systematic Review, Dalal Alomar

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NOD1/NOD2 Upregulation in Fusobacterium Nucleatum Induced NETosis, Hanadi Alyami

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Necessity of Keratinized Tissue Around Dental Implants to Maintain Peri-Implant Tissue Health: A Systematic Review, Rawan K. Kamal

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Effect of Expansive Force on Mesenchymal Stem Cells Isolated From the Mid-Palatal Suture of Mice, Samaneh Mojarrad

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Using The Rat Grimace Scale to Detect Orofacial Pain in Mechanically-induced Temporomandibular Joint Pain in Rats, Ya-Hsin Yu, Megan M. Sperry, Beth A. Winkelstein, and Eric J. Granquist

Theses/Dissertations from 2017

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P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Subjected to Mechanical Strain, Farraj S. Albalawi, Wennan Lu, Jonarhan M. Beckel, Jason C. Lim, Stuart A. McCaughey, and Claire H. Mitchell

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FOXO1 Deletion Reverses the Effect of Diabetic-Induced Impaired Fracture Healing, Mohammed A. Alharbi

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Patient Related Outcomes for Dental Implant Therapy with Fixed Prostheses: A Systematic Review, Ahmed M. Kabli

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Do Buffered Local Anesthetics Provide More Successful Anesthesia Over Non-Buffered Solutions in Patients Requiring Dental Therapy? – A Systematic Review & Meta-Analysis., Sereen Kattan, Bekir Karabucak, Elliot V. Hersh, Johnathan M. Korostoff, and Paul Hunter

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The Role of Mas-Related G-Protein Receptor X2 (MRGPRX2) on Neuropeptide Induced Reponses in Human Mast Cells, Wichayapha Manorak

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Modulatory Role of Severe Hypoxia in Orofacial Mesenchymal Stem Cell (OFMSC) Plasticity, Temitope T. Omolehinwa (nee Odukoya)

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Mesenchymal Stem Cell (MSC) Spheroid Constructs Containing Microfluidic BMP2-PLGA Microcapsules in Bone Tissue Engineering., Bhavendrasinh Sayania

Anti-inflammatory Effect of Secoisolariciresinol Diglucoside (SDG) in Microglia, Kevin B. Seto, Kelly L. Jordan-Sciutto, Beth A. Winkelstein, Bekir Karabucak, and Eric J. Granquist

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Effects of Mechanical Stretch on Stem Cells from Human Exfoliated Deciduous Teeth (SHED), Katherine Zhang

Theses/Dissertations from 2016

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Dentin Remineralization Around Ceramir Restoration, Lujain S. Alhuwayrini

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The Requirement of p53 in Oral MSC differentiation Which Leads to Kaposi’s Sarcoma, May Alsenani

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RANKL From Osteocytes Contributes to Periodontal Bone Loss, Ahmed Alshabab

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Novel Endodontic Disinfection Approach Using Nanotechnology, Sarah Bukhari, Bekir Karabucak, and Hyun Koo

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Review of Approaches to Caries Treatment, Cherissa Chong

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FOXO1 Differentially Regulates Both Normal and Diabetic Gingival Wound Healing, Hyeran H. Jeon

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Microfluidic PLGA Microcapsules for the Sustained Delivery of Recombinant Human Bone Morphogenetic Protein 2 in 3D Printed PCL/βTCP Scaffolds, Sara M. Kasten

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Effect RANKL Produced by Periodontal Ligament Cells on Orthodontic Tooth Movement, Chia-Ying Yang

Theses/Dissertations from 2015

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Postnatal Regulation of Bone Growth by Muscle IGF-1, HyeYoon Helen Choi

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The Mast Cell Receptor Mas-Related Gene X2 (MrgX2) in Health and Disease, Chizobam N. Idahosa

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Investigation of Wnt5a and sFRP5 Expressions in Healthy and Chronic Periodontitis Tissues, Pacharee Kulwattanaporn

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Role of NLRP3 Inflammasome in Pathogenesis of Pulpal Disease, Su-Min Lee

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Milk Fat Globule-Epidermal Growth Factor-Factor 8 (MFG-E8) as a Novel Biomarker for Periodontal Disease, Fatimah A. Meshikhes

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A Multivariate Analysis of the Outcome of Endodontic Microsurgery Using MTA or ERRM as Root-End Filling Material: A Randomized Clinical Trial With Cone-Beam Computed Tomography Evaluation, Chafic Safi

Theses/Dissertations from 2014

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Epigenetic Changes in the Innate Response of Gingival Epithelium, Mahsa Abdolhosseini

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Characterization of Mandible and Femur Canine Mesenchymal Stem Cells: A Pilot Study, Juan M. Bugueno

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Analysis of BiP Expression in the Cervical and Lumbar Spinal Cord Following Painful Whole-Body Vibration, Kosuke Tanaka

Theses/Dissertations from 2013

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Lysosomal pH and the Control of Genes Involved in Inflammation and Degradation, Sara A. Khan